EA201692017 НОВЫЕ КЛЕТОЧНО-ПРОНИЦАЕМЫЕ СУКЦИНАТНЫЕ СОЕДИНЕНИЯ

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Eurasian Patent Organization

Application Number 201692017

Application Date 08.04.2015

Publication Number 201692017

Publication Date 28.02.2017

Grant Number 035678

Grant Date 24.07.2020

Publication Kind B1

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Applicants НЬЮРОУВИВ ФАРМАСЬЮТИКАЛ АБ
NEUROVIVE PHARMACEUTICAL AB

Inventors Элмер Эскил
Ханссон Магнус Йоаким
Эингер Карл Хенрик Йоханнес
Мосс Стивен
ELMER Eskil
HANSSON Magnus, Joakim
EHINGER Karl, Henrik, Johannes
MOSS Steven

Agents Медведев Валерий Николаевич
Medvedev Valery, N.

Priority Data PA 2014 70190 08.04.2014 DK

Title

(RU) НОВЫЕ КЛЕТОЧНО-ПРОНИЦАЕМЫЕ СУКЦИНАТНЫЕ СОЕДИНЕНИЯ

Abstract

(RU)

Изобретение предоставляет новые клеточно-проницаемые сукцинаты и клеточно-проницаемые предшественники сукцината, направленные на увеличение производства АТФ в митохондриях. Основная часть производимой АТФ и используемой в эукариотической клетке создается при митохондриальном окислительном фосфорилировании процесса, по которому высокоэнергетические электроны предоставляются циклом Кребса. Не все полупродукты цикла Кребса являются легко проницаемыми для клеточной мембраны, одним из них является сукцинат. Предоставление новых клеточно-проницаемых сукцинатов предусмотрено для обеспечения возможности их проникновения через клеточную мембрану, и такие клеточно-проницаемые сукцинаты могут быть использованы для усиления эффекта производства АТФ, относящегося к митохондриям.

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
21	Esters, e.g. nitroglycerine, selenocyanates
215	of carboxylic acids
22	of acyclic acids, e.g. pravastatin
225	Polycarboxylic acids

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
21	Esters, e.g. nitroglycerine, selenocyanates
215	of carboxylic acids
22	of acyclic acids, e.g. pravastatin
225	Polycarboxylic acids

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8	Cosmetics or similar toilet preparations
18	characterised by the composition
30	containing organic compounds
46	containing sulfur

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8	Cosmetics or similar toilet preparations
18	characterised by the composition
30	containing organic compounds
49	containing heterocyclic compounds
4906	with one nitrogen as the only hetero atom
4926	having six membered rings

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8	Cosmetics or similar toilet preparations
18	characterised by the composition
30	containing organic compounds
49	containing heterocyclic compounds
4973	with oxygen as the only hetero atom
498	having 6-membered rings or their condensed derivatives, e.g. coumarin

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1. EA201692017 - НОВЫЕ КЛЕТОЧНО-ПРОНИЦАЕМЫЕ СУКЦИНАТНЫЕ СОЕДИНЕНИЯ

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
Q	SPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
19	Preparations for care of the skin

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
C	ACYCLIC OR CARBOCYCLIC COMPOUNDS
327	Thiocarboxylic acids
20	Esters of monothiocarboxylic acids
28	having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
211	Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
04	with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
68	having one double bond between ring members or between a ring member and a non-ring member
72	with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
74	Oxygen atoms
76	attached in position 2 or 6

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9	Drugs for disorders of the cardiovascular system

Y	SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
02	TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
A	TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
50	in human health protection, e.g. against extreme weather
30	Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
2800	Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
10	General cosmetic use