EA201600236 ПРОИЗВОДНЫЕ 1,2,4-ОКСАДИАЗОЛА В КАЧЕСТВЕ ИММУНОМОДУЛЯТОРОВ

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Eurasian Patent Organization

Application Number 201600236

Application Date 05.09.2014

Publication Number 201600236

Publication Date 31.08.2016

Grant Number 030155

Grant Date 29.06.2018

Publication Kind B1

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Applicants АУРИГЕН ДИСКАВЕРИ ТЕКНОЛОДЖИЗ ЛИМИТЕД
AURIGENE DISCOVERY TECHNOLOGIES LIMITED

Inventors Сасикумар Потайил Говиндан Наир
Рамачандра Муралидхара
Наремаддепалли Сизарамайах Сетти Сударшан
SASIKUMAR Pottayil, Govindan, Nair
RAMACHANDRA Muralidhara
NAREMADDEPALLI Seetharamaiah, Setty, Sudarshan

Agents Тагбергенова Модангуль Маруповна
Тагбергенова Алма Таишевна
Tagbergenova Modangoul, M.
Tagbergenova Alma, Taishevna

Priority Data 4011/CHE/2013 06.09.2013 IN

Title

(RU) ПРОИЗВОДНЫЕ 1,2,4-ОКСАДИАЗОЛА В КАЧЕСТВЕ ИММУНОМОДУЛЯТОРОВ

Abstract

(RU)

Настоящее изобретение относится к соединениям 1,2,4-оксадиазола в качестве терапевтических средств, способных ингибировать сигнальный путь программируемой смерти клеток - 1 (PD-1). Изобретение также относится к производным этих терапевтических средств. Кроме того, изобретение относится к применению указанных терапевтических средств и их производных для лечения расстройств и нарушений нормальной работы организма посредством иммуностимуляции, включающей ингибирование иммуносупрессивного сигнала, индуцированного вследствие PD-1, PD-L1 или PD-L2, а также к терапии или лечению с их помощью.

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
271	Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
02	not condensed with other rings
06	1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
271	Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
02	not condensed with other rings
06	1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41	having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
433	Thidiazoles

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
273	Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
08	having two nitrogen atoms and more than one oxygen atom

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41	having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
4245	Oxadiazoles

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1. EA201600236 - ПРОИЗВОДНЫЕ 1,2,4-ОКСАДИАЗОЛА В КАЧЕСТВЕ ИММУНОМОДУЛЯТОРОВ

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1	Drugs for disorders of the alimentary tract or the digestive system

Y	SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
02	TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
A	TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
50	in human health protection, e.g. against extreme weather
30	Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Y	SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
10	TECHNICAL SUBJECTS COVERED BY FORMER USPC
S	TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
514	Drug, bio-affecting and body treating compositions
885	Immune response affecting drug