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1. EA201600236 - ПРОИЗВОДНЫЕ 1,2,4-ОКСАДИАЗОЛА В КАЧЕСТВЕ ИММУНОМОДУЛЯТОРОВ

Office
Eurasian Patent Organization
Application Number 201600236
Application Date 05.09.2014
Publication Number 201600236
Publication Date 31.08.2016
Grant Number 030155
Grant Date 29.06.2018
Publication Kind B1
IPC
C07D 271/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
271Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
02not condensed with other rings
061,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
CPC
A61K 31/433
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
433Thidiazoles
C07D 273/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
273Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
08having two nitrogen atoms and more than one oxygen atom
A61K 31/4245
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
4245Oxadiazoles
C07D 271/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
271Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
02not condensed with other rings
061,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
A61K 31/395
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
C07D 273/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
273Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
Applicants АУРИГЕН ДИСКАВЕРИ ТЕКНОЛОДЖИЗ ЛИМИТЕД
AURIGENE DISCOVERY TECHNOLOGIES LIMITED
Inventors Сасикумар Потайил Говиндан Наир
Рамачандра Муралидхара
Наремаддепалли Сизарамайах Сетти Сударшан
SASIKUMAR Pottayil, Govindan, Nair
RAMACHANDRA Muralidhara
NAREMADDEPALLI Seetharamaiah, Setty, Sudarshan
Agents Тагбергенова Модангуль Маруповна
Тагбергенова Алма Таишевна
Tagbergenova Modangoul, M.
Tagbergenova Alma, Taishevna
Priority Data 4011/CHE/2013 06.09.2013 IN
Title
(RU) ПРОИЗВОДНЫЕ 1,2,4-ОКСАДИАЗОЛА В КАЧЕСТВЕ ИММУНОМОДУЛЯТОРОВ
Abstract
(RU)

Настоящее изобретение относится к соединениям 1,2,4-оксадиазола в качестве терапевтических средств, способных ингибировать сигнальный путь программируемой смерти клеток - 1 (PD-1). Изобретение также относится к производным этих терапевтических средств. Кроме того, изобретение относится к применению указанных терапевтических средств и их производных для лечения расстройств и нарушений нормальной работы организма посредством иммуностимуляции, включающей ингибирование иммуносупрессивного сигнала, индуцированного вследствие PD-1, PD-L1 или PD-L2, а также к терапии или лечению с их помощью.