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1. DK3738957 - FREMGANGSMÅDE TIL ACETYLERING AF CANNABINOIDER

Office
Denmark
Application Number 20158964
Application Date 24.02.2020
Publication Number 3738957
Publication Date 20.09.2021
Grant Number 3738957
Grant Date 20.09.2021
Publication Kind T3
IPC
C07D 311/82
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
311Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
02ortho- or peri-condensed with carbocyclic rings or ring systems
78Ring systems having three or more relevant rings
80Dibenzopyrans; Hydrogenated dibenzopyrans
82Xanthenes
B01D 3/10
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
3Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping
10Vacuum distillation
B01D 3/14
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
3Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping
14Fractional distillation
B01D 3/34
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
3Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping
34with one or more auxiliary substances
B01D 11/04
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
11Solvent extraction
04of solutions which are liquid
CPC
B01D 3/10
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
3Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping
10Vacuum distillation
B01D 3/143
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
3Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping
14Fractional distillation ; or use of a fractionation or rectification column
143by two or more of a fractionation, separation or rectification step
B01D 3/346
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
3Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping
34with one or more auxiliary substances
343the substance being a gas
346the gas being used for removing vapours, e.g. transport gas
B01D 11/0492
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
11Solvent extraction
04of solutions which are liquid
0492Applications, solvents used
C07D 311/82
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
311Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
02ortho- or peri-condensed with carbocyclic rings or ring systems
78Ring systems having three or more relevant rings
80Dibenzopyrans; Hydrogenated dibenzopyrans
82Xanthenes
A61K 31/352
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
35having six-membered rings with one oxygen as the only ring hetero atom
352condensed with carbocyclic rings, e.g. cannabinols, methantheline
Applicants NextLeaf Solutions Ltd.
Inventors KO, Ryan Delmoral
HUGHES, Brock
PAL, Krupal Devendra
CASSELMAN, Ivan Jason
Priority Data 16415782 17.05.2019 US
Title
(DA) FREMGANGSMÅDE TIL ACETYLERING AF CANNABINOIDER
Abstract
(EN) A process for producing THC-O-acetate using a succession of distillation, salting-out assisted liquid-liquid extractions (SALLEs), and solvent recovery techniques. Tetrahydrocannabinol (THC) in cannabis oil reacts with acetic anhydride under reflux to produce THC-O-acetate and acetic acid. The resulting crude product is distilled and subjected to a SALLE with hexane followed by a SALLE with petroleum ether, before being distilled again in order to obtain a refined, THC-O-acetate product.