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1. DK0837843 - Fremgangsmåde til fremstilling af enantiomere former af aminoalkylaminophenylpropansyre

Office Denmark
Application Number 96922085
Application Date 10.06.1996
Publication Number 0837843
Publication Date 19.11.2001
Grant Number
Grant Date 19.11.2001
Publication Kind T3
IPC
C07C 229/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
229Compounds containing amino and carboxyl groups bound to the same carbon skeleton
02having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
04the carbon skeleton being acyclic and saturated
06having only one amino and one carboxyl group bound to the carbon skeleton
10the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
12to carbon atoms of acyclic carbon skeletons
C07C 227/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
227Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
14from compounds containing already amino and carboxyl groups or derivatives thereof
CPC
C07C 227/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
227Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
14from compounds containing already amino and carboxyl groups or derivatives thereof
C07C 229/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
229Compounds containing amino and carboxyl groups bound to the same carbon skeleton
02having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
04the carbon skeleton being acyclic and saturated
06having only one amino and one carboxyl group bound to the carbon skeleton
10the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
12to carbon atoms of acyclic carbon skeletons
Applicants Aventis Pharma S.A.
Inventors STAMMLER, Robert
Priority Data 9506890 12.06.1995 FR
Title
(DA) Fremgangsmåde til fremstilling af enantiomere former af aminoalkylaminophenylpropansyre
Abstract
(EN)
A method for preparing an enantiomeric form of 2-amino-3-(4-alkylaminophenyl)propanoic acid of general formula (I), wherein Alk is a C1-2 alkyl radical in (S) or (R) form, and salts thereof, from (L)-phenylalanine and (D)-phenylalanine respectively, by nitration followed by conversion of the nitro radical of the resulting 4-nitro phenylalanine of general formula (II), wherein R is a hydrogen atom or a protective radical, into an alkylamino radical, optionally after having protected the amine function of the phenylalanine.