DE102020118255 Deuterierte und tritiierte N-(4,5-Dimethylthiazol-2(3H)-yliden)-2,2,3,3-tetramethylcyclopropan-1-carboxamid-Derivate und deren Verwendung

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Germany

Application Number 102020118255

Application Date 10.07.2020

Publication Number 102020118255

Publication Date 13.01.2022

Publication Kind A1

IPC

CPC

Applicants Helmholtz-Zentrum Dresden - Rossendorf e. V.

Inventors Moldovan Rares-Petru
Teodoro Rodrigo
Toussaint Magali
Gündel Daniel
Deuther-Conrad Winnie
Brust Peter

Agents Riechelmann & Carlsohn Patentanwälte PartG mbB

Title

(DE) Deuterierte und tritiierte N-(4,5-Dimethylthiazol-2(3H)-yliden)-2,2,3,3-tetramethylcyclopropan-1-carboxamid-Derivate und deren Verwendung

Abstract

(DE)

Die Erfindung betrifft Verbindungen der allgemeinen Formel I embedded image worin X¹ eine CD₂-Gruppe oder eine CT₂-Gruppe ist; X² Sauerstoff oder eine Gruppe (CZ¹Z²)_n ist, wobei Z¹ und Z² bei jedem Auftreten unabhängig voneinander jeweils Wasserstoff, Deuterium oder Tritium sind und n eine Ganzzahl von 1 bis 12 ist; X³ eine CD₂-Gruppe oder eine CT₂-Gruppe ist; und R aus der Gruppe ausgewählt ist, die aus Hydroxy, -NO₂, Halogen, einem Diazonium-Ion, einem Diazonium-Salz, einem Trialkylammonium-Ion, einem Trialkylammonium-Salz, einem Dialkoxyaren, einem Sulfoxid, einer Boronsäure, einem Boronsäureester, einer zinnorganischen Verbindung, einem Iodonium-Ion, einem Iodonium-Salz, einem Iodonium-Ylid und einem Sulfonat besteht. embedded image

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
277	Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
02	not condensed with other rings
20	having two or three double bonds between ring members or between ring members and non-ring members
32	with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
38	Nitrogen atoms
44	Acylated amino or imino radicals
46	by carboxylic acids, or sulfur or nitrogen analogues thereof

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41	having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
425	Thiazoles
426	1,3-Thiazoles

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25	Drugs for disorders of the nervous system
04	Centrally acting analgesics, e.g. opioids

G	PHYSICS
01	MEASURING; TESTING
T	MEASUREMENT OF NUCLEAR OR X-RADIATION
1	Measuring X-radiation, gamma radiation, corpuscular radiation, or cosmic radiation
16	Measuring radiation intensity
161	Applications in the field of nuclear medicine, e.g. in vivo counting
164	Scintigraphy

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
277	Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
02	not condensed with other rings
20	having two or three double bonds between ring members or between ring members and non-ring members
32	with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
38	Nitrogen atoms
44	Acylated amino or imino radicals
46	by carboxylic acids, or sulfur or nitrogen analogues thereof

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1. DE102020118255 - Deuterierte und tritiierte N-(4,5-Dimethylthiazol-2(3H)-yliden)-2,2,3,3-tetramethylcyclopropan-1-carboxamid-Derivate und deren Verwendung

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
B	GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
59	Introduction of isotopes of elements into organic compounds ; ; Labelled organic compounds per se
002	Heterocyclic compounds