Processing

Please wait...

Settings

Settings

Goto Application

1. DE102020118255 - Deuterierte und tritiierte N-(4,5-Dimethylthiazol-2(3H)-yliden)-2,2,3,3-tetramethylcyclopropan-1-carboxamid-Derivate und deren Verwendung

Office
Germany
Application Number 102020118255
Application Date 10.07.2020
Publication Number 102020118255
Publication Date 13.01.2022
Publication Kind A1
IPC
C07D 277/46
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
277Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
02not condensed with other rings
20having two or three double bonds between ring members or between ring members and non-ring members
32with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
38Nitrogen atoms
44Acylated amino or imino radicals
46by carboxylic acids, or sulfur or nitrogen analogues thereof
A61K 31/426
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
425Thiazoles
4261,3-Thiazoles
A61P 25/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
04Centrally acting analgesics, e.g. opioids
G01T 1/164
GPHYSICS
01MEASURING; TESTING
TMEASUREMENT OF NUCLEAR OR X-RADIATION
1Measuring X-radiation, gamma radiation, corpuscular radiation, or cosmic radiation
16Measuring radiation intensity
161Applications in the field of nuclear medicine, e.g. in vivo counting
164Scintigraphy
CPC
C07D 277/46
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
277Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
02not condensed with other rings
20having two or three double bonds between ring members or between ring members and non-ring members
32with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
38Nitrogen atoms
44Acylated amino or imino radicals
46by carboxylic acids, or sulfur or nitrogen analogues thereof
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
C07B 59/002
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
59Introduction of isotopes of elements into organic compounds ; ; Labelled organic compounds per se
002Heterocyclic compounds
Applicants Helmholtz-Zentrum Dresden - Rossendorf e. V.
Inventors Moldovan Rares-Petru
Teodoro Rodrigo
Toussaint Magali
Gündel Daniel
Deuther-Conrad Winnie
Brust Peter
Agents Riechelmann & Carlsohn Patentanwälte PartG mbB
Title
(DE) Deuterierte und tritiierte N-(4,5-Dimethylthiazol-2(3H)-yliden)-2,2,3,3-tetramethylcyclopropan-1-carboxamid-Derivate und deren Verwendung
Abstract
(DE)

Die Erfindung betrifft Verbindungen der allgemeinen Formel I embedded imageworin X1 eine CD2-Gruppe oder eine CT2-Gruppe ist; X2 Sauerstoff oder eine Gruppe (CZ1Z2)n ist, wobei Z1 und Z2 bei jedem Auftreten unabhängig voneinander jeweils Wasserstoff, Deuterium oder Tritium sind und n eine Ganzzahl von 1 bis 12 ist; X3 eine CD2-Gruppe oder eine CT2-Gruppe ist; und R aus der Gruppe ausgewählt ist, die aus Hydroxy, -NO2, Halogen, einem Diazonium-Ion, einem Diazonium-Salz, einem Trialkylammonium-Ion, einem Trialkylammonium-Salz, einem Dialkoxyaren, einem Sulfoxid, einer Boronsäure, einem Boronsäureester, einer zinnorganischen Verbindung, einem Iodonium-Ion, einem Iodonium-Salz, einem Iodonium-Ylid und einem Sulfonat besteht. embedded image


Related patent documents