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1. CZ2000-1886 - Alfa-hydroxy, alfa-amino a alfa-haloderiváty ß-sulfonylhydroxamových kyselin jako inhibitory matricových metaloproteináz

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Czech Republic
Application Number 2000-1886
Application Date 18.11.1998
Publication Number 2000-1886
Publication Date 15.11.2000
Publication Kind A3
IPC
A61K 31/195
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19Carboxylic acids, e.g. valproic acid
195having an amino group
A61P 19/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
C07C 317/48
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
317Sulfones; Sulfoxides
44having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
48the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
C07C 317/44
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
317Sulfones; Sulfoxides
44having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
A61P 19/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
08for bone diseases, e.g. rachitism, Paget's disease
10for osteoporosis
Applicants PHARMACIA & UPJOHN COMPANY
Inventors Martha A. Warpehoski
Mark Allen Mitchell
Donald E. Harper
Linda Louise Maggiora
Agents Ivana Jirotková
Priority Data 1997 072655 21.11.1997 US
Title
(CS) Alfa-hydroxy, alfa-amino a alfa-haloderiváty ß-sulfonylhydroxamových kyselin jako inhibitory matricových metaloproteináz
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Abstract
(CS) Sloučeniny vzorce I nebo jejich farmaceuticky přijatelné soli, přičemž R1je C4-12 alkyl, C4-12 alkenyl, C4-12 alkinyl, -(CH2) h-C3-8 cykloalkyl, substituovaný a nesubstituovaný - (CH2) h-aryl, substituovaný a nesubstituovaný -(CH2) h-het, R2 je substituovaný a nesubstituovaný C1-12 alkyl, substituovaný a nesubstituovaný C2-12 alkenyl, substituovaný a nesubstituovaný C2-12 alkinyl, substituovaný a nesubstituovaný -(CH2) h-C3-8 cykloalkyl, substituovaný a nesubstituovaný -(CH2) h-C3-8 cykloalkenyl, substituovaný a nesubstituovaný -(CH) h-aryl, substituovaný a nesubstituovaný -(CH2) h-heterocyklický kruh, substituovaný a nesubstituovaný -(CH2) i-X-R4 (X je -O-, -S(=O) j-, -NR7-, -S(=O) 2NR8-, nebo -C(=O)-) a -(CH2) iCHR5R6. Sloučeniny jsou inhibitory matricových metaloproteináz účastnících se degradace tkání.
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