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1. CU23252 - POLIPÉPTIDOS INNOVADORES CD19 X CD3 ESPECÍFICOS Y SU UTILIZACIÓN

Office
Cuba
Application Number 20000223
Application Date 20.10.2000
Publication Number 23252
Publication Date 17.12.2007
Publication Kind B7
IPC
C07K 14/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 48/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A61K 2039/505
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
505comprising antibodies
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 37/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
C07K 16/2803
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
2803against the immunoglobulin superfamily
Applicants MICROMET AG
Inventors Anja Löffler
Ralf Bargou
Ralf Lutterbüse
Peter Kufer
Agents MICROMET AG
Priority Data 9807269.7A 21.04.1998 EP
Title
(ES) POLIPÉPTIDOS INNOVADORES CD19 X CD3 ESPECÍFICOS Y SU UTILIZACIÓN
Abstract
(ES) Se describen los polipéptidos multifuncionales de cadena simple innovadores que comprenden por lo menos dos sitios aglomerantes específicos para el antígeno CD19 y CD3, respectivamente. Además se proveen polipéptidos donde el polipéptido antes descrito comprende por lo menos un dominio adicional, preferentemente de función predeterminada. Además, se describen los polinucleótidos y células huésped transformadas ahí y su utilización en la producción de estos polipéptidos. Se describe también la utilización de los polipéptidos, los polinucleótidos y los vectores antes mencionados para la preparación de composiciones farmacéuticas para la inmunoterapia, preferentemente contra malignidades de la célula B como el linfoma que no es de tipo Hodgkin.


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