CU24362 DERIVADOS DE 1,2,4-OXADIAZOL COMO INMUNOMODULADORES

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Cuba

Application Number 2016000029

Application Date 05.09.2014

Publication Number 24362

Publication Date 04.10.2018

Publication Kind B1

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CPC

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Applicants AURIGENE DISCOVERY TECHNOLOGIES LTD.

Inventors Naremaddepalli, Seetharamaiah Setty Sudarshan
Ramachandra, Muralidhara
Sasikumar, Pottayil Govidan Nair

Priority Data 4011/CHE/2013 06.09.2013 IN

Title

(ES) DERIVADOS DE 1,2,4-OXADIAZOL COMO INMUNOMODULADORES

Abstract

(ES)

La presente invención se refiere a compuestos 1,2,4-oxadiazol y 1,2,4-tiadiazol como agentes terapéuticos capaces de inhibir la vía de señalización de la muerte celular programada 1 (PD1). La invención además se refiere a derivados de los agentes terapeúticos. La invención además abarca el uso de dichos agentes terapeúticos y derivados para el tratamiento de los trastornos a través de inmunopotenciación que comprende la inhibición de la señal inmunosupresiva inducida debido a PD-1, PD-L1 ó PD-L2 y las terapias donde se usan.

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41	having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4245	Oxadiazoles

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41	having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
433	Thiadiazoles

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
271	Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
02	not condensed with other rings
06	1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
285	Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/-C07D283/183
01	Five-membered rings
02	Thiadiazoles; Hydrogenated thiadiazoles
04	not condensed with other rings
08	1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41	having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4245	Oxadiazoles

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1. CU24362 - DERIVADOS DE 1,2,4-OXADIAZOL COMO INMUNOMODULADORES

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1	Drugs for disorders of the alimentary tract or the digestive system

Y	SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
02	TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
A	TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
50	in human health protection, e.g. against extreme weather
30	Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Y	SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
10	TECHNICAL SUBJECTS COVERED BY FORMER USPC
S	TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
514	Drug, bio-affecting and body treating compositions
885	Immune response affecting drug