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1. CR20210432 - METHODS OF PURIFYING AN ALLERGEN EXTRACT

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Office
Costa Rica
Application Number 20210432
Application Date 26.03.2019
Publication Number 20210432
Publication Date 05.01.2022
Publication Kind A
IPC
A61K 35/36
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
36Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
A61K 35/35
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
35Fat tissue; Adipocytes; Stromal cells; Connective tissues 
A61K 35/646
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
56Materials from animals other than mammals
63Arthropods
646Arachnids, e.g. spiders, scorpions, ticks or mites
CPC
A61K 35/35
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
35Fat tissue; Adipocytes; Stromal cells; Connective tissues
A61K 35/36
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
36Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
A61K 35/646
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
56Materials from animals other than mammals
63Arthropods
646Arachnids, e.g. spiders, scorpions, ticks or mites
A61K 35/68
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
68Protozoa, e.g. flagella, amoebas, sporozoans, plasmodium or toxoplasma
A61K 36/63
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18Magnoliophyta (angiosperms)
185Magnoliopsida (dicotyledons)
63Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
A61K 36/899
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18Magnoliophyta (angiosperms)
88Liliopsida (monocotyledons)
899Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
Applicants LETI PHARMA S.L.
Inventors CARNÉS SÁNCHEZ, Jerónimo
GALLEGO, María Teresa
ROMÁN-ESCUTIA, Marta
MORALES, María
Agents SIMÓN ALFREDO VALVERDE GUTIERREZ
Priority Data 19382030.5 17.01.2019 EP
Title
(EN) METHODS OF PURIFYING AN ALLERGEN EXTRACT
(ES) MÉTODOS PARA PURIFICAR UN EXTRACTO DE ALÉRGENO
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Abstract
(EN)

The invention relates to processes for producing semi-purified and purified allergen extracts and pharmaceutical compositions and vaccines for use in the diagnosis and treatment of allergy. In one aspect of the invention, a process for producing a depigmented allergen extract is provided, the process comprising: a) basifying a native allergen extract; and b) removing molecules having a molecular size of less than 3.5 kDa; and c) adjusting the pH to neutrality; thereby to produce a depigmented allergen extract.


(ES)

La invención se refiere a procesos para producir extractos de alérgenos semipurificados y purificados y composiciones farmacéuticas y vacunas para uso en el diagnóstico y tratamiento de alergia.

            En un aspecto de la invención, se proporciona un proceso para producir un extracto de alérgeno despigmentado, el proceso que comprende:

            a) basificar un extracto de alérgeno nativo; y

            b) remover moléculas que tienen un tamaño molecular de menos de 3,5 kDa; y

            c) ajustar el pH a neutralidad;

            para producir de este modo un extracto de alérgeno despigmentado.
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