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1. CO20210007230 - INHIBIDORES DE CINASA 7 DEPENDIENTE DE CICLINA (CDK7)

Office
Colombia
Application Number 20210007230
Application Date 31.05.2021
Publication Number 20210007230
Publication Date 29.10.2021
Publication Kind A2
IPC
A61K 31/4523
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non-condensed pyridines; Hydrogenated derivatives thereof
445Non-condensed piperidines, e.g. piperocaine
4523containing further heterocyclic ring systems
A61K 31/519
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
C07F 9/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9Compounds containing elements of Groups 5 or 15 of the Periodic System
02Phosphorus compounds
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants SYROS PHARMACEUTICALS, INC.
Inventors Jason J. MARINEAU
Claudio CHUAQUI
Michael BRADLEY
Stephane CIBLAT
Anzhelika KABRO
Agents CAROLINA MERCEDES DAZA MONTALVO
Priority Data 62/754,398 01.11.2018 US
62/877,189 22.07.2019 US
62/915,983 16.10.2019 US
62/927,469 29.10.2019 US
Title
(ES) INHIBIDORES DE CINASA 7 DEPENDIENTE DE CICLINA (CDK7)
Abstract
(ES) La presente invención proporciona diversas composiciones, que incluyen compuestos de la Fórmula (I) o (Ia), o una especie de las mismos, y sales farmacéuticamente aceptables, solvatos (por ejemplo, hidratos), estereoisómeros, tautómeros, formas isotópicas y otras formas específicas de los mismos. También se proporcionan métodos (o usos) y kits que implican los compuestos o composiciones farmacéuticamente aceptables que los contienen para tratar o prevenir una enfermedad (por ejemplo, una enfermedad proliferativa tal como cáncer) en un sujeto. La administración de un compuesto o composición farmacéutica descrita en la presente se espera para inhibir cinasa 7 dependiente de ciclina (CDK7), y de este modo, inducir la apoptosis en células tumorales en un sujeto.
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