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1. CO6270330 - 2-FLUORO-2`-DESOXITETRAHIDROURIDINAS COMO INHIBIDORES DE CITIDINA DESAMINASA

Office
Colombia
Application Number 10057462
Application Date 13.05.2010
Publication Number 6270330
Publication Date 20.04.2011
Publication Kind A2
IPC
C07H 19/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02sharing nitrogen
04Heterocyclic radicals containing only nitrogen as ring hetero atom
CPC
A61K 31/7068
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7042Compounds having saccharide radicals and heterocyclic rings
7052having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
706containing six-membered rings with nitrogen as a ring hetero atom
7064containing condensed or non-condensed pyrimidines
7068having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 35/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
02specific for leukemia
A61P 35/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
04specific for metastasis
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
C07H 1/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
1Processes for the preparation of sugar derivatives
Applicants EISAI INC
Inventors GREGORY ,HAMILTON
TAKASHI ,TSUKAMOTO
DANNA ,FERRARIS
BRIDGET ,DUVALL
RENA ,LAPIDUS
Priority Data 60/980.397 16.10.2007 US
Title
(ES) 2-FLUORO-2`-DESOXITETRAHIDROURIDINAS COMO INHIBIDORES DE CITIDINA DESAMINASA
Abstract
(ES) La presente invención provee determinados compuestos derivados de tetrahidrouridina, composiciones farmacéuticas y kits que comprenden tales compuestos y métodos de preparación y uso de tales compuestos.1.- Un compuesto de la fórmula I, o una de sus sales farmacéuticamente aceptables:en donde el carbono marcado con un asterisco puede tener una configuración (R) o (S); y en donde R1 y R2 están seleccionados, de modo independiente, de flúor e hidrógeno, siempre que R1 y R2 no sean ambos hidrógeno.2.- Un compuesto de la fórmula I seleccionado del grupo que consiste en en donde cada átomo de carbono marcado con un * tiene una configuración estereoquímica está seleccionado del grupo que consiste en una configuración (R), une configuración (S) o una mezcla de configuraciones (R) y (S); y sus sales farmacéuticamente aceptables.3.- El compuesto de acuerdo con la reivindicación 2, en donde el compuesto es el compuesto 1.
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