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1. CN103717735 - Technique for cleaving out part of poly(a) chain and/or 3'-terminal sequence of mRNA to inhibit translation reaction

Office
China
Application Number 201280036289.1
Application Date 17.07.2012
Publication Number 103717735
Publication Date 09.04.2014
Grant Number 103717735
Grant Date
Publication Kind A
IPC
C12N 15/09
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
A01K 67/027
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
67Rearing or breeding animals, not otherwise provided for; New breeds of animals
027New breeds of vertebrates
A61K 31/7105
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
7105Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
A61K 31/713
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
713Double-stranded nucleic acids or oligonucleotides
A61K 48/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
CPC
A01K 67/027
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
67Rearing or breeding animals, not otherwise provided for; New breeds of animals
027New breeds of vertebrates
A01K 2207/05
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2207Modified animals
05Animals modified by non-integrating nucleic acids, e.g. antisense, RNAi, morpholino, episomal vector, for non-therapeutic purpose
A01K 2227/40
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2227Animals characterised by species
40Fish
A01K 2267/03
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2267Animals characterised by purpose
03Animal model, e.g. for test or diseases
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants PUBLIC UNIV CORP YOKOHAMA CITY
YOSHINDO INC
NATIONAL UNIVERSITY CORPORATION TOKYO INSTITUTE OF TECHNOLOGY
Inventors WADA TADASHI
TAKEDA KEI
HANDA HIROSHI
Agents luo juhua
Priority Data 2011-160512 22.07.2011 JP
Title
(EN) Technique for cleaving out part of poly(a) chain and/or 3'-terminal sequence of mRNA to inhibit translation reaction
(ZH) 切断mRNA的多聚(A)链和/或3’末端序列的一部分而抑制翻译反应的技术
Abstract
(EN)
Provided is an artificial gene expression inhibition method which can be designed more readily compared with conventional methods (an RNAI method, a ribozyme method, an antisense method), and in which the effect thereof can be confirmed readily. Provided are: a method for inhibiting the translation reaction of a target gene, which comprises cleaving out a part of a poly(A) chain and/or a 3'-terminal sequence of target mRNA; a kit for inhibiting a translation reaction, which comprises a reagent capable of cleaving out a part of a poly(A) chain and/or a 3'-terminal sequence of target mRNA; a cell into which a reagent capable of cleaving out a part of a poly(A) chain and/or a 3'-terminal sequence of target mRNA is introduced so as to inhibit the translation reaction of a target gene; and a non-human living organism into which a reagent capable of cleaving out a part of a poly(A) chain and/or a 3'-terminal sequence of target mRNA is introduced so as to inhibit the translation reaction of a target gene.

(ZH)

本发明提供相比以往方法(RNAi法-核酶法-反义法)设计更简便,并且效果的确认也容易的人为的基因表达抑制方法。包括切断目标mRNA的多聚(A)链和/或3’末端序列的一部分来抑制目标基因的翻译反应的方法。也提供含可切断目标mRNA的多聚(A)链和/或3’末端序列的一部分的试剂的、用于抑制翻译反应的试剂盒;导入了可切断目标mRNA的多聚(A)链和/或3’末端序列的一部分的试剂的、而使目标基因的翻译反应被抑制的细胞;及导入了可切断目标mRNA的多聚(A)链和/或3’末端序列的一部分的试剂的、目标基因的翻译反应进而被抑制的非人生物。