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1. (CN102725283) Compounds and compositions as protein kinase inhibitors

Office : China
Application Number: 201080038197.8 Application Date: 27.08.2010
Publication Number: 102725283 Publication Date: 10.10.2012
Grant Number: 102725283 Grant Date: 26.02.2014
Publication Kind : B
Prior PCT appl.: Application Number:PCTUS2010046930 ; Publication Number:2011025927 Click to see the data
IPC:
C07D 401/14
C07D 403/04
A61K 31/506
A61P 35/00
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
506
not condensed and containing further heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants: IRM LLC
Novartis AG
Inventors: Huang Shenlin
Jin Xianming
Liu Zuosheng
Poon Daniel
Tellew John
Wan Yongqin
Wang Xing
Xie Yongping
Agents: huang gesheng lin bainan
Priority Data: 61/238,073 28.08.2009 US
61/313,039 11.03.2010 US
Title: (EN) Compounds and compositions as protein kinase inhibitors
(ZH) 作为蛋白激酶抑制剂的化合物和组合物
Abstract: front page image
(EN) The invention provides a novel class of compounds of formula 1, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf.
(ZH)

本发明提供了一类新的式I化合物、含有此类化合物的药物组合物以及采用此类化合物治疗或预防疾病或障碍的方法,所述疾病或障碍与激酶活性异常或失控有关,尤其是涉及B-Raf异常激活的疾病或障碍。


Also published as:
RSP-2014/0430UAa201203042SG178351IL218084EP2470526DOP2012000051
JP2013503186CA2771775EA201200373EP2727918ES2492499KR1020120062839
TN2012000081NZ598924DK2470526AU2010286569VN30470ID2012/03594
TH140028IN2469/DELNP/2012WO/2011/025927