CN102596204 Novel nucleic acid prodrugs and methods use thereof

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Application Number 201080039607.0

Application Date 06.07.2010

Publication Number 102596204

Publication Date 18.07.2012

Grant Number 102596204

Grant Date 23.11.2016

Publication Kind B

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Applicants 波涛生命科学有限公司

Inventors 格雷戈里·L·沃迪恩
米纳
娜奥基·艾娃莫托

Agents 北京英赛嘉华知识产权代理有限责任公司 11204
北京英赛嘉华知识产权代理有限责任公司 11204

Priority Data 61/223,369 06.07.2009 US
61/242,722 15.09.2009 US

Title

(EN) Novel nucleic acid prodrugs and methods use thereof

(ZH) 新的核酸前药及其使用方法

Abstract

(EN) Described herein are nucleic acid prodrugs and nucleic acid prodrugs comprising chiral phosphorous moieties. Also described herein are methods of making and using nucleic acid prodrugs and nucleic acid prodrugs comprising chiral phosphorous moieties.

(ZH) 本文公开了核酸前药和包含手性磷部分的核酸前药。本文还公开了制备和使用核酸前药和包含手性磷部分的核酸前药的方法。

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
70	Carbohydrates; Sugars; Derivatives thereof

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
70	Carbohydrates; Sugars; Derivatives thereof

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
70	Carbohydrates; Sugars; Derivatives thereof

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1	Drugs for disorders of the alimentary tract or the digestive system
18	for pancreatic disorders, e.g. pancreatic enzymes

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3	Drugs for disorders of the metabolism
02	Nutrients, e.g. vitamins, minerals

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1. CN102596204 - Novel nucleic acid prodrugs and methods use thereof

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
F	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9	Compounds containing elements of Groups 5 or 15 of the Periodic System
02	Phosphorus compounds
547	Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
655	having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
65515	the oxygen atom being part of a five-membered ring

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
H	SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21	Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids