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1. (CN102356081) 减少β-淀粉状蛋白生成的双环化合物

Office : China
Application Number: 201080012637.2 Application Date: 12.01.2010
Publication Number: 102356081 Publication Date: 15.02.2012
Grant Number: 102356081 Grant Date: 27.08.2014
Publication Kind : B
Prior PCT appl.: Application Number:PCTUS2010020710 ; Publication Number:2010083141 Click to see the data
IPC:
C07D 471/04
C07D 487/04
A61K 31/437
A61K 31/4196
A61P 25/28
C07D 417/12
C07D 513/10
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
4353
ortho- or peri-condensed with heterocyclic ring systems
437
the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4196
1,2,4-Triazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
28
for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
417
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
513
Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/, C07D477/232
02
in which the condensed system contains two hetero rings
10
Spiro-condensed systems
CPC:
C07D 487/04
C07D 417/12
C07D 471/04
C07D 513/10
Applicants: 百时美施贵宝公司
Inventors: L·R·马钦
L·A·汤普森三世
K·M·博伊
J·M·盖尔农
M·A·希金斯
施建良
邬永金
Agents: 中国专利代理(香港)有限公司 72001
中国专利代理(香港)有限公司 72001
Priority Data: 61/145319 16.01.2009 US
Title: (ZH) 减少β-淀粉状蛋白生成的双环化合物
Abstract: front page image
(ZH)

本公开提供一系列式(I)化合物,其减少β-淀粉状肽(β-AP)生成并用于治疗阿尔茨海默氏病和受β-淀粉状肽(β-AP)生成影响的其它疾病,其中A是含有独立地选自氮、氧和硫的1-3个杂原子的5-或6-元杂芳环;B选自苯基和吡啶基,D选自式(II),E选自Ci-e烷基、Cd-e环烷基、苄基、苯基和含有一个或两个氮原子的5-6元杂芳环。


Also published as:
AR075139EP2379553JP2012515205ES2426023IN4927/DELNP/2011WO/2010/083141