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1. (CN102264723) Dihydropyridone amides as p2x7 modulators

Office : China
Application Number: 200980152176.6 Application Date: 14.12.2009
Publication Number: 102264723 Publication Date: 30.11.2011
Publication Kind : A
Prior PCT appl.: Application Number:PCTEP2009067026 ; Publication Number:2010072597 Click to see the data
IPC:
C07D 401/12
C07D 413/12
A61K 31/44
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
413
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
CPC:
C07D 401/12
C07D 413/12
Applicants: Hoffmann La Roche
霍夫曼-拉罗奇有限公司
Inventors: Berger Jacob
雅各布·伯格
Caroon Joan Marie
约恩·玛丽·卡伦
Krauss Nancy Elisabeth
南希·伊丽沙白·克劳斯
Lopez-tapia Francisco Javier
弗朗西斯科·哈维尔·洛佩兹-塔比亚
Walker Keith Adrian Murray
基思·阿迪安·默里·沃克
Zhao Shu-hai
赵树海
Agents: wang xu
中科专利商标代理有限责任公司 11021
Priority Data: 61/203,482 23.12.2008 US
Title: (EN) Dihydropyridone amides as p2x7 modulators
(ZH) 作为P2X7调节剂的二氢吡啶酮酰胺
Abstract: front page image
(EN) Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, R1, R2, R3, R4, R5 and Ra are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with the P2X7 purinergic receptor.
(ZH)

式I化合物或其药用盐,其中m、n、R1、R2、R3、R4、R5和Ra如本文所定义。还公开了制备所述化合物和使用所述化合物用于治疗与P2X7嘌呤能受体有关的疾病的方法。


Also published as:
AR074843IL213417MXMX/a/2011/006232SG172336EP2385939JP2012513433
CA2745864MX2011006232KR1020110086768AU2009331659IN4420/CHENP/2011WO/2010/072597