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1. (CN102256595) Method of making small liposomes

Office : China
Application Number: 200980150953.3 Application Date: 17.12.2009
Publication Number: 102256595 Publication Date: 23.11.2011
Publication Kind : A
Prior PCT appl.: Application Number:PCTUS2009068499 ; Publication Number:2010078045 Click to see the data
IPC:
A61K 9/127
C07K 14/775
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
127
Liposomes
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
775
Apolipopeptides
CPC:
C07F 9/10
A61K 9/1277
A61K 39/00
Applicants: Oncothyreon Inc.
肿瘤防护公司
Inventors: Dupuit Robert A.
R·A·迪皮
Reilley William J.
W·J·赖利
Agents: ma chongde ai niwaer
中国专利代理(香港)有限公司 72001
中国专利代理(香港)有限公司 72001
Priority Data: 61/138353 17.12.2008 US
Title: (EN) Method of making small liposomes
(ZH) 制备小粒径脂质体的方法
Abstract: front page image
(EN) Liposomes of constrained particle size are prepared by substantially continuously mixing substantially continuously flowing streams of water, and of an organic solvent contain lipid(s) capable of forming liposomes, and cooling the mixture so liposomes form, the ratio of the flow rate of the stream of water to the flow rate of the stream of organic solvent, and the rate of cooling of said mixture, being controlled so as to obtain a preparation of liposomes such that at least about 90% of the liposomes are of a particle size less than about 200 nm.
(ZH)

制备具有特定粒径的脂质体,通过基本持续地混合基本上持续的水流和基本上持续的有机溶剂流,所述有机溶剂包含能形成脂质体的脂质,并冷却所述混合物以形成脂质体,控制水流流速对有机溶剂流的流速之比以及所述混合物的冷却速度以使获得至少约90%的脂质体的粒径小于约200nm。


Also published as:
EP2367532SG172257JP2012512260US20120034294CA2747182EA201100829
JP2014224127MX2011006562KR1020110094114CN105935352AU2009333177AU2013273711
IN2997/KOLNP/2011BRPI0923001WO/2010/078045