(EN) Disclosed is an antibody capable of binding specifically to the human c-Met receptor and/or capable of specifically inhibiting the tyrosine kinase activity of said receptor, said antibody having an improved antagonistic activity, said antibody comprising a modified hinge region. Disclosed also are a composition comprising such an antibody antagonist to c-Met and its use as a medicament for treating cancer.
(ZH)
能够特异性结合人c-Met受体和/或能够特异性抑制所述受体的酪氨酸激酶活性的抗体，所述抗体具有提高的拮抗活性，所述抗体包含修饰的铰链区。包含这样的c-Met的抗体拮抗剂的组合物及其作为用于治疗癌症的药物的用途。
CNCM I-3731
20070314
