CN101855200 New polymorphic forms of N-[4-(trifluoromethyl)benzyl]-4-methoxybutyramide

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China

Application Number 200880115643.3

Application Date 12.11.2008

Publication Number 101855200

Publication Date 06.10.2010

Grant Number 101855200

Grant Date 07.05.2014

Publication Kind B

IPC

CPC

Applicants C.T.制药实验室有限责任公司

Inventors 罗伯特·卡恰利亚
马西莫·弗雷里

Agents 广州华进联合专利商标代理有限公司 44224

Priority Data 07120551 13.11.2007 EP

Title

(EN) New polymorphic forms of N-[4-(trifluoromethyl)benzyl]-4-methoxybutyramide

(ZH) N-[4-(三氟甲基)苯甲基]-4-甲氧基丁酰胺的多晶型物

Abstract

(EN) Crystalline polymorphic forms of a compound of formula N-[4-(trifluoromethyl)benzyl]-4-methoxybutyramide are described. The two polymorphic forms, named polymorphic Form A and polymorphic Form B, can be used in the treatment of drug addiction and alcoholism and have very good stability. Methods for preparing the polymorphic forms are also described.

(ZH)

本发明公开了分子式是N-[4-(三氟甲基)苯甲基]-4-甲氧基丁酰胺的化合物的结晶多晶型物。被称为多晶型物A和多晶型物B的这两种多晶型物可以用于药物依赖和酒精中毒的治疗，并且具有非常好的稳定性。本发明还公开了制备所述多晶型物的方法。

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
C	ACYCLIC OR CARBOCYCLIC COMPOUNDS
235	Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
02	having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
04	the carbon skeleton being acyclic and saturated
06	having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
16	Amides, e.g. hydroxamic acids
165	having aromatic rings, e.g. colchicine, atenolol, progabide

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25	Drugs for disorders of the nervous system
30	for treating abuse or dependence

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
C	ACYCLIC OR CARBOCYCLIC COMPOUNDS
235	Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
02	having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
04	the carbon skeleton being acyclic and saturated
06	having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
16	Amides, e.g. hydroxamic acids
165	having aromatic rings, e.g. colchicine, atenolol, progabide

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1. CN101855200 - New polymorphic forms of N-[4-(trifluoromethyl)benzyl]-4-methoxybutyramide

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
B	GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
2200	Indexing scheme relating to specific properties of organic compounds
13	Crystalline forms, e.g. polymorphs