CN101575363 Synthetic methods for aplidine and new antitumoral derivatives, methods of making and using them

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Application Number 200810183709.4

Application Date 02.07.2001

Publication Number 101575363

Publication Date 11.11.2009

Grant Number 101575363

Grant Date 27.01.2016

Publication Kind B

IPC

Applicants 法马马有限公司

Inventors I·罗德里古滋
C·珀兰科
F·丘瓦斯
P·曼德滋
C·丘瓦斯
P·加勒戈
S·蒙特
I·曼扎纳雷斯

Agents 中国专利代理(香港)有限公司 72001
中国专利代理(香港)有限公司 72001

Priority Data 0016148.9 30.06.2000 GB
0103750.6 15.02.2001 GB

Title

(EN) Synthetic methods for aplidine and new antitumoral derivatives, methods of making and using them

(ZH) Aplidine及新抗肿瘤衍生物的合成方法、及其制备和使用方法

Abstract

(EN) The invention relates to synthetic methods for aplidine and new antitumoral derivatives, methods of making and using them. The invention provides aplidine derivatives and synthetic methods. They are represented by the formula: where the different symbols have the meaning indicated in the description.

(ZH)

本发明涉及Aplidine及新抗肿瘤衍生物的合成方法、及其制备和使用方法。本发明提供aplidine衍生物及合成方法。所述化合物由下式表示：其中各种符号的含义在说明书中描述。

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
11	Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
11	Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
02	cyclic, e.g. valinomycins

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38	Medicinal preparations containing peptides
04	Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
C	ACYCLIC OR CARBOCYCLIC COMPOUNDS
271	Derivatives of carbamic acid, i.e. compounds containing any of the groups the nitrogen atom not being part of nitro or nitroso groups
06	Esters of carbamic acids
08	having oxygen atoms of carbamate groups bound to acyclic carbon atoms
10	with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
22	to carbon atoms of hydrocarbon radicals substituted by carboxyl groups

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35	Antineoplastic agents

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1. CN101575363 - Synthetic methods for aplidine and new antitumoral derivatives, methods of making and using them