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1. CN101426813 - Immunomodulatory and anti-tumour peptides

Office
China
Application Number 200780013884.2
Application Date 23.02.2007
Publication Number 101426813
Publication Date 06.05.2009
Grant Number 101426813
Grant Date 04.04.2012
Publication Kind B
IPC
C07K 14/435
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
A61K 38/17
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 35/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
04specific for metastasis
A61P 37/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
04Immunostimulants
C07K 14/43509
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
43504from invertebrates
43509from crustaceans
Applicants Ct Ingenieria Genetica Biotech
遗传工程与生物技术中心
Inventors Guillen Nieto Gerardo Enrique
M·格拉巴列斯皮
Guerra Vallespi Maribel
I·D·C·托伦斯马德拉索
Torrens Madrazo Isis Del Carme
O·雷伊斯阿考斯塔
Garay Perez Hilda Elisa
H·E·加雷佩雷兹
Reyes Benitez Jose Fernando
G·E·吉伦涅托
Acevedo Castro Boris Ernesto
B·E·阿塞韦多卡斯特罗
Ubieta Gomez Raimundo
R·乌比塔戈麦斯
Agents luo juhua du jingyang
中国国际贸易促进委员会专利商标事务所 11038
中国国际贸易促进委员会专利商标事务所 11038
Priority Data 20060047 24.02.2006 CU
Title
(EN) Immunomodulatory and anti-tumour peptides
(ZH) 具有免疫调节和抗肿瘤能力的肽
Abstract
(EN)
The invention relates to the development of peptides originating from sequence HYRIKPTFRRLKWKKYKGKFW, into which amino acid substitutions have been introduced, which guarantee the dissociation of the lipopolysaccharide-binding capacity and potentiate the anti-tumour and immunomodulatory effect. Said peptides and combinations thereof can be used in the treatment of cancer, as well as in synergism with other standard therapies.

(ZH)

本发明涉及开发衍生自其中引入了氨基酸置换的序列HYRIKPTFRRLKWKKYKGKFW的肽,所述肽不能与脂多糖结合并具有免疫调节和抗肿瘤作用。所述肽或其组合用于治疗癌症,以及与常规疗法协同地用于治疗癌症。