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1. (CN101232904) Neuroprotective effective compound

Office : China
Application Number: 200680028017.1 Application Date: 23.06.2006
Publication Number: 101232904 Publication Date: 30.07.2008
Publication Kind : A
Prior PCT appl.: Application Number:PCTUS2006024656 ; Publication Number:2007002512 Click to see the data
IPC:
A61K 48/00
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
CPC:
A61K 48/005
A61K 38/1875
Applicants: Tissuegene Inc.
组织基因公司
Inventors: Lee Kwan-hee
李宽熙
Lee Duk-keun
李德根
Yi Young-suk
李泳锡
Noh Moon-jong
卢文钟
Kim Hyoung-chun
金滢春
Agents: zhangshe gao libing lin
北京康信知识产权代理有限责任公司
北京康信知识产权代理有限责任公司
Priority Data: 60/595,342 23.06.2005 US
Title: (EN) Neuroprotective effective compound
(ZH) 有效的神经保护性化合物
Abstract: front page image
(EN) The present application discloses a method of preventing degeneration of nerve, which includes: a) generating a recombinant viral or plasmid vector comprising a DNA sequence encoding a member of a transforming growth factor superfamily or neurotrophic factor proteins operatively linked to a promoter; b) transfecting in vitro a population of cultured cells with the recombinant vector, resulting in a population of the cultured cells; and c) transplanting the transfected cells to an area near an injured nerve, such that expression of the DNA sequence within the area near the injured nerve causes prevention of degeneration of the nerve.
(ZH)

本申请披露了一种预防神经变性的方法,它包括:a)生成一种重组病毒或质粒载体,该重组病毒或质粒载体包含编码转化生长因子超家族或神经营养因子蛋白中的一员的DNA序列,该DNA序列可操作地连接于启动子;b)用所述重组载体在体外转染一群培养细胞,得到一个所述培养细胞的种群;以及c)将所述转染的细胞移植至受损神经附近的区域,使得所述DNA序列在受损神经附近区域内表达从而预防所述神经的变性。


Also published as:
KR1020080038310KR1020100074340EP1904113JP2009506982CA2613551JP2014088425
KR1020130101595KR1020140132010ES2562243KR1020160021458DK1904113CN106177996
AU2006261889AU2010257453IN10145/DELNP/2007KR1020180057737WO/2007/002512