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1. (CN101222931) Cynara scolymus extracts, the use thereof and formulations containing them

Office : China
Application Number: 200680025389.9 Application Date: 16.06.2006
Publication Number: 101222931 Publication Date: 16.07.2008
Publication Kind : A
Prior PCT appl.: Application Number:PCTEP2006005778 ; Publication Number:2007006391 Click to see the data
IPC:
A61K 36/28
A61P 3/06
A61P 1/00
A61P 9/10
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36
Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18
Magnoliophyta (angiosperms)
185
Magnoliopsida (dicotyledons)
28
Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
06
Antihyperlipidemics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1
Drugs for disorders of the alimentary tract or the digestive system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
10
for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
CPC:
A61K 36/28
A61K 36/185
A61K 36/55
Applicants: Indena SPA
因德纳有限公司
Inventors: Bomvardelli Ezio
E·邦巴尔代利
Fontana Gabriele
G·丰塔纳
Giori Andrea
A·焦里
Morazzoni Paolo
P·莫拉佐尼
Ronchi Massimo
M·龙基
Arpini Sabrina
S·阿匹尼
Agents: huangge sheng lingli
北京市中咨律师事务所
北京市中咨律师事务所
Priority Data: MI2005A001347 14.07.2005 IT
Title: (EN) Cynara scolymus extracts, the use thereof and formulations containing them
(ZH) 洋蓟提取物、其用途以及含有其的制剂
Abstract:
(EN) The present invention relates to the preparation of a Cynara scolymus extract obtainable by fractioning on a resin. The process of the invention allows to obtain an extract, starting from the aerial parts of the plant Cynara scolymus, containing three classes of active principles, namely dicaffeoylquinic acids, luteolin and cynaropicrin glycosides, in a constant ratio. Cynaropicrin is stabilized by addition of precise amounts of sulfated amino acids or suitable thio-derivatives. These extracts have hypolipemizing, anti-dyspeptic and vascular anti-inflammatory activities. The extracts are mainly formulated in Enothera biennis oil or in oils rich in Omega-3 and Omega-6 acids which enhance the vascular activity.
(ZH)

本发明涉及可以通过树脂分级获得的洋蓟提取物的制备。本发明的方法允许从洋蓟植物的地上部分开始获得提取物,该提取物包含恒定比例的三类活性成分,即二咖啡酰奎尼酸、木犀草素和菜蓟苦素苷。通过添加精确量的硫酸化氨基酸或合适的硫代衍生物可以稳定菜蓟苦素。这些提取物具有降血脂、抗消化不良和抗血管炎症的活性。该提取物主要在月见草油或可以提高血管活性的富含ω-3和ω-6酸的油类中配制。


Also published as:
NO20080198NZ565025KR1020080038127EP1906983JP2009501708US20090285911
CA2614796AU2006269035IN160/KOLNP/2008WO/2007/006391