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1. (CN101217948) Percutaneously absorptive ophthalmic preparation comprising epinastine

Office : China
Application Number: 200680024979.X Application Date: 07.07.2006
Publication Number: 101217948 Publication Date: 09.07.2008
Publication Kind : A
Prior PCT appl.: Application Number:PCTJP2006314005 ; Publication Number:2007007851 Click to see the data
IPC:
A61K 9/70
A61K 9/107
A61K 9/06
A61P 37/08
A61P 27/14
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
70
Web, sheet or filament bases
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
107
Emulsions
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
06
Ointments; Bases therefor
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
08
Antiallergic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
27
Drugs for disorders of the senses
02
Ophthalmic agents
14
Decongestants or antiallergics
CPC:
A61K 9/7023
A61K 9/0048
A61K 9/06
A61K 9/107
Applicants: Senju Pharma Co.
千寿制药株式会社
Inventors: Isowaki Akiharu
礒脇明治
Fujimoto Tomoko
中岛朋子
Ohtori Akira
大鸟聪
Agents: guanli xin liangmou
中国专利代理(香港)有限公司
中国专利代理(香港)有限公司
Priority Data: 60/697,369 08.07.2005 US
Title: (EN) Percutaneously absorptive ophthalmic preparation comprising epinastine
(ZH) 包含依匹那丁的透皮吸收眼科制剂
Abstract:
(EN) The present invention provides a percutaneously absorptive preparation for preventing or treating allergic eye disease, which comprises epinastine or a salt thereof as an active ingredient. In addition, the present invention provides a method for preventing or treating allergic eye disease, which comprises applying a percutaneously absorptive preparation comprising epinastine or a salt thereof to the skin surface including the skin surface of an eyelid, thereby causing transfer of a therapeutically effective amount of epinastine or a salt thereof from the preparation to an anterior ocular segment through the skin of the eyelid rather than a systemic blood flow. The present preparation can exert a pharmacological effect over a prolonged period by a single application, as compared to conventional preparations such as eye drops.
(ZH)

本发明提供用于预防或治疗变应性眼病的透皮吸收制剂,该制剂包含依匹那丁或其盐作为活性成分。此外,本发明提供预防或治疗变应性眼病的方法,该方法包括向包括眼睑皮肤表面的皮肤表面施用包含依匹那丁或其盐的透皮吸收制剂,由此使治疗有效量的依匹那丁或其盐通过眼睑皮肤而非系统血流从制剂中转移到眼的前方部位。与常规制剂如滴眼液相比,本发明的制剂通过单次应用就能表现出长效药理作用。


Also published as:
KR1020080034916EP1901724JP2009500397US20090143359IN687/CHENP/2008WO/2007/007851