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1. (CN101217981) Composition and dosage form comprising a solid or semi-solid matrix

Office : China
Application Number: 200680024594.3 Application Date: 22.06.2006
Publication Number: 101217981 Publication Date: 09.07.2008
Publication Kind : A
Prior PCT appl.: Application Number:PCTEP2006006026 ; Publication Number:2007003278 Click to see the data
IPC:
A61K 47/22
A61K 9/00
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
22
Heterocyclic compounds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
CPC:
A61K 9/146
A61K 9/1694
A61K 9/2013
A61K 9/2027
A61K 31/4184
A61K 31/5415
A61K 47/22
Applicants: Abbott GmbH & Co. KG
阿伯特有限及两合公司
Inventors: Rosenberg Joerg
J·罗森波格
Maegerlein Markus
M·梅格莱因
Breitenbach Joerg
J·布艾恩芭克
Agents: huangge sheng jiashi cong
北京市中咨律师事务所
北京市中咨律师事务所
Priority Data: 05014555.6 05.07.2005 EP
60/595,435 05.07.2005 US
Title: (EN) Composition and dosage form comprising a solid or semi-solid matrix
(ZH) 包含固体或半固体基质的组合物和剂型
Abstract:
(EN) A composition which comprises a solid or semi-solid matrix having at least one active ingredient uniformly dispersed therein, the matrix comprising at least one pharmaceutically acceptable matrix-forming agent and a 1,3-bis(lactamyl)-butane compound, in particular 1,3-bis(pyrrolidon-1-yl)-butane. The active ingredient is preferably dispersed in the matrix in a state of a solid solution. The matrix-forming agent is preferably a pharmaceutically acceptable polymer. The composition is useful for the manufacture of pharmaceutical dosage forms.
(ZH)

本发明涉及一种组合物,其包含其中均匀分散有至少一种活性成分的固体或半固体基质,所述基质包含至少一种可药用的基质形成剂和1,3-双(内酰胺基)-丁烷化合物,特别是1,3-双(吡咯烷酮-1-基)-丁烷。活性成分优选地以固体溶液状态分散在基质中。基质形成剂优选地是可药用的聚合物。所述组合物可用于制备药物剂型。


Also published as:
EP1898954JP2009500301US20090220596RU0002423997CA2612864IN72/CHENP/2008
WO/2007/003278