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1. (CN101217979) Self-buffering protein formulations

Office : China
Application Number: 200680021395.7 Application Date: 08.06.2006
Publication Number: 101217979 Publication Date: 09.07.2008
Publication Kind : A
Prior PCT appl.: Application Number:PCTUS2006022599 ; Publication Number:2006138181 Click to see the data
IPC:
A61K 39/395
C12P 21/08
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
21
Preparation of peptides or proteins
08
Monoclonal antibodies
CPC:
A61K 39/39591
A61K 9/08
A61K 39/3955
C07K 16/241
C07K 16/2803
C07K 16/2827
C07K 16/2866
C07K 16/2875
C07K2317/565
C07K2317/94
Applicants: Amgen Inc.
安姆根有限公司
Inventors: Gokarn Yatin R.
Y·R·戈卡恩
Kras Eva
E·克拉斯
Remmele Richard Louis Jr.
R·L·小雷梅尔
Brems David N.
D·N·布雷姆斯
Hershenson Susan Irene
S·I·赫尔申森
Agents: zhangdie dong liangmou
中国专利代理(香港)有限公司
中国专利代理(香港)有限公司
Priority Data: 60/690,582 14.06.2005 US
Title: (EN) Self-buffering protein formulations
(ZH) 自缓冲蛋白制剂
Abstract: front page image
(EN) The invention herein described, provides, among other things, self-buffering protein formulations. Particularly, the invention provides self-buffering pharmaceutical protein formulations that are suitable for veterinary and human medical use. The self-buffering protein formulations are substantially free of other buffering agents, stably maintain pH for the extended time periods involved in the distribution and storage of pharmaceutical proteins for veterinary and human medical use. The invention further provides methods for designing, making, and using the formulation. In addition to other advantages, the formulations avoid the disadvantages associated with the buffering agents conventionally used in current formulations of proteins for pharmaceutical use. The invention in these and other respects can be productively applied to a wide variety of proteins and is particularly useful for making and using self-buffering formulations of pharmaceutical proteins for veterinary and medical use, especially, in particular, for the treatment of diseases in human subjects.
(ZH)

在此所述的本发明提供自缓冲的蛋白制剂。特别地,本发明提供适合于兽医和人医用途的自缓冲的药物蛋白制剂。该自缓冲的蛋白制剂基本上不含其它的缓冲剂,在包括用于兽医和人医用途的药物蛋白的分配和存储的延长时间周期内,稳定地保持pH。本发明还提供设计、制造和使用该制剂的方法。除其它优点外,该制剂还避免了与常规在当前用于药物用途的蛋白制剂中使用的缓冲剂有关的缺点。在这些以及其它方面,本发明可以有效地应用于各种蛋白,特别是可用于制备和使用用于兽医和医学用途的药物蛋白的自缓冲制剂,特别是用于在人受试者中治疗疾病。


Also published as:
MXMX/a/2007/015476KR1020080031684IL188102SG162788EP1909831ZA2008/00338
JP2008543839US20080311078BRPI0611901JP2013047261CA2610839EA200800050
JP2016053061AU2006259664AU2012272950AU2015242973AU2017202889IN5286/CHENP/2007
JP2018048196EP3351269WO/2006/138181