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1. CN101208292 - Method for producing amines from hydroxamic acids

Office China
Application Number 200680022716.5
Application Date 05.07.2006
Publication Number 101208292
Publication Date 25.06.2008
Publication Kind A
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
209
Preparation of compounds containing amino groups bound to a carbon skeleton
54
by rearrangement reactions
56
from carboxylic acids involving a Hofmann, Curtius, Schmidt, or Lossen-type rearrangement
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
269
Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups the nitrogen atom not being part of nitro or nitroso groups
C07C 209/56
C07C 269/00
CPC
C07C 269/00
C07C 209/56
Applicants Archimica GmbH
齐明药化
Inventors Meudt Andreas
A·莫伊特
Boehm Claudius
C·伯姆
Agents yinjun
中国国际贸易促进委员会专利商标事务所
Priority Data 102005032592.0 11.07.2005 DE
Title
(EN) Method for producing amines from hydroxamic acids
(ZH) 由异羟肟酸制备胺类的方法
Abstract
(EN)
A method for producing unprotected or carbamate-protected amines of formulae (II) and (III) or R<1> - NH2 (II) or R<1> - NHCO2R<2> (III) by reacting hydroxamic acids of formula (I) (R<1> CONHOH) with a) alkylphosphonic acid anhydrite's, b) alcohol R<2>OH and c) optionally with a base, at a temperature ranging from 100 to +120 DEG C, wherein the hydroxamic acid (I) is produced prior to or during reacting (in situ) and R<1> is an optionally substituted linear or branched C1C12 alkyl radical, substituted C3-C10 cycloalkyl, alkenyl, aryl or heteroaryl radical and R<2> is an open-chain, cyclic or branched aIIyI, aryl or C<1> to C<12>-alkyl radicals, or aryloxy, allyloxy or alkoxy radical possibly substituted with open-chain, cyclic or branched C<1> to C<12>-alkyl radicals.

(ZH)

用于制备未保护的或经氨基甲酸酯保护的式(II)和(III)的胺类的方法,R1-NH2(II)或R1-NHCO2R2(III),其通过在-100~+120℃的温度范围下,使式(I)的异羟肟酸(R1CONHOH)与a.)烷基膦酸酐,b.)醇R2OH和c.)任选地碱反应,其中所述异羟肟酸(I)在反应前或者在反应期间(原位)产生,且R1是任选地经取代的直链或支化的C1-C12-烷基残基,经取代的C3-C10-环烷基、烯基、芳基或杂芳基残基,和R2是烯丙基、芳基、开链、环状或支化的C1至C12-烷基残基,任选地经开链、环状或支化的C1至C12-烷基残基取代的芳氧基、烯丙氧基或烷氧基残基。