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1. CN101146815 - A process for the preparation of 6-o-methyl erythromycin a derivative

Office China
Application Number 200680009512.8
Application Date 20.03.2006
Publication Number 101146815
Publication Date 19.03.2008
Publication Kind A
IPC
C07H 1/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
1Processes for the preparation of sugar derivatives
CPC
C07H 1/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
1Processes for the preparation of sugar derivatives
Applicants Ind Swift Lab Ltd.
因-斯韦特实验室有限公司
Inventors Srinivasan Chidambaram Venkate
C·V·斯里尼瓦桑
Saxena Rahul
R·萨克西那
Gupta Pranav
P·古普塔
Agents liangchao yu
北京金之桥知识产权代理有限公司
Title
(EN) A process for the preparation of 6-o-methyl erythromycin a derivative
(ZH) 一种制备6-O-甲基红霉素A衍生物的方法
Abstract
(EN)
The present invention relates to an improved process for the preparation of 6-O-methylerythromycin A derivatives, intermediates of clarithromycin, by selective methylation of erythromycin A derivative in a mixture of a acyclic or cyclic alkanes having C<SUB>6</SUB>-C<SUB>10</SUB> carbon atoms, and a polar aprotic solvent using a methylating agent in the presence of a base under mild conditions.

(ZH)

本发明涉及一种制备6-O-甲基红霉素衍生物的改进方法,克拉霉素的中间体,是通过在温和的反应条件下,在C6-C10个碳原子的直链或环烷烃和一种极性惰性溶剂的混合物中,加有碱并使用甲基化剂时,红霉素衍生物发生选择性甲基化作用而制得。

Also published as
EP6728411
ESP200750057
MXMX/a/2007/011749