Processing

Please wait...

Settings

Settings

Goto Application

1. CN101116086 - Methods and apparatus for reading for encoding microbeads

Office
China
Application Number 200580046616.1
Application Date 16.11.2005
Publication Number 101116086
Publication Date 30.01.2008
Publication Kind A
IPC
G06K 7/10
GPHYSICS
06COMPUTING; CALCULATING OR COUNTING
KRECOGNITION OF DATA; PRESENTATION OF DATA; RECORD CARRIERS; HANDLING RECORD CARRIERS
7Methods or arrangements for sensing record carriers
10by electromagnetic radiation, e.g. optical sensing; by corpuscular radiation
CPC
B01J 2219/00459
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
2219Chemical, physical or physico-chemical processes in general; Their relevant apparatus
00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
00277Apparatus
00457Dispensing or evacuation of the solid phase support
00459Beads
B01J 2219/005
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
2219Chemical, physical or physico-chemical processes in general; Their relevant apparatus
00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
00277Apparatus
00497Features relating to the solid phase supports
005Beads
B01J 2219/00704
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
2219Chemical, physical or physico-chemical processes in general; Their relevant apparatus
00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
0068Means for controlling the apparatus of the process
00702Processes involving means for analysing and characterising the products
00704integrated with the reactor apparatus
B82Y 20/00
BPERFORMING OPERATIONS; TRANSPORTING
82NANOTECHNOLOGY
YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
20Nanooptics, e.g. quantum optics or photonic crystals
G01N 15/1468
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
15Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
10Investigating individual particles
14Electro-optical investigation, e.g. flow cytometers
1468with spatial resolution of the texture or inner structure of the particle
G02B 1/005
GPHYSICS
02OPTICS
BOPTICAL ELEMENTS, SYSTEMS, OR APPARATUS
1Optical elements characterised by the material of which they are made
002made of materials engineered to provide properties not available in nature, e.g. metamaterials
005made of photonic crystals or photonic band gap materials
Applicants Illumina Inc.
伊路敏纳公司
Inventors Moon John A.
J·A·穆恩
Agents liuchun yuan zhangzhi cheng
中国专利代理(香港)有限公司
中国专利代理(香港)有限公司
Priority Data 60/628,897 16.11.2004 US
Title
(EN) Methods and apparatus for reading for encoding microbeads
(ZH) 读取编码微珠的方法和设备
Abstract
(EN) A method and apparatus for reading a microbead having a code thereon is provided wherein the code is projected on and read from a Fourier plane. The microbead may be 1-1000 microns (um) or smaller in feature size. The code is projected on the Fourier plane by scattering input light off the microbead. The scattered light from the microbead is directed through an optical arrangement having a transform lens for projecting the code on the Fourier plane, and read on the Fourier plane using a charge coupled device (CCD) or other similar device. The code may include periodic layers of material having different refractivities or phase, including index of refraction differences; periodic spatial modulations having a different phase or amplitude; a periodic binary phase change used to code information in the Fourier plane; a photonic crystal used to encode the information on the microbead, wherein a pattern of holes causes interference between incident and scattered light to form spatial and spectral patterns in the far field that are unique to the pattern of holes; or may be formed in the microbead using a single photoactive inner region, a series of longitudinal holes, different fluorescence regions, or concentric rings of material in a preform.
(ZH)

提供一种用于读取其上具有代码的微珠的方法和设备,其中代码被投射在傅里叶平面上并且从傅里叶平面读取该代码。微珠的形体尺寸可以是1-1000微米(μm)或更小。通过使入射光散射离开微珠而将代码投射在傅里叶平面上。将从微珠散射的光引导通过具有用于将代码投射在傅里叶平面上的变换透镜的光学装置,并利用电荷耦合器件(CCD)或其他类似装置在傅里叶平面上读取代码。代码可以包括具有不同折射率或相位、包括折射率差的周期性材料层;具有不同相位或振幅的周期性空间调制;用于对傅里叶平面内的信息进行编码的周期性二元相位变化;用于对微珠上的信息进行编码的光子晶体,其中穿孔图案导致入射光和散射光之间的干涉在远场中形成空间和光谱特性曲线,这些空间和光谱特性曲线对于穿孔图案是唯一的;或者可以利用单个光敏内区、一系列纵向孔、不同的荧光区、或者预制件中的材料的同心环而在微珠中形成代码。