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1. CN1972722 - IFBM'S to promote attachment of target analytes

Office China
Application Number 200580019812.X
Application Date 15.06.2005
Publication Number 1972722
Publication Date 30.05.2007
Publication Kind A
IPC
A61L 27/22
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
14Macromolecular materials
22Polypeptides or derivatives thereof
A61L 27/34
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
28Materials for coating prostheses
34Macromolecular materials
G01N 33/543
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
543with an insoluble carrier for immobilising immunochemicals
Applicants Affinergy Inc.
阿费内基有限公司
Inventors Hamilton Paul T.
保罗·T·汉密尔顿
Grinstaff Mark W.
马克·W·格林斯塔夫
Kenan Daniel J.
丹尼尔·J·凯南
Christensen Dale J.
戴尔·J·克里斯滕森
Beyer Wayne Fl Jr.
小韦恩·F1·拜耶
Hyde-Deruyscher Robin
罗宾·海德·德鲁勒
Benson Ray Edward
雷·爱德华·本森
Agents wanhua tang
中国商标专利事务所有限公司
Priority Data 60/580,019 16.06.2004 US
11133805 19.05.2005 US
11174705 05.07.2005 US
Title
(EN) IFBM'S to promote attachment of target analytes
(ZH) 促进目标分析物附着的IFBM'S
Abstract
(EN)
The present invention provides an improved coating for surfaces of medical implants. The coating comprises at least one interfacial biomaterial (IFBM) which is comprised of at least one binding module that binds to the surface of an implant or implant-related material ('implant module') and at least one binding module that selectively binds to a target analyte or that is designed to have a desired effect ('analyte module'). The modules are connected by a linker. In some embodiments, the IFBM coating acts to promote the recognition and attachment of target analytes to surface of the device. The IFBM coating improves the performance of implanted medical devices, for example, by promoting osteointegration of the implant.

(ZH)

本发明提供一种改进的医疗植入物表面涂层。涂层包括至少一种界面生物材料(IFBM),界面生物材料包括至少一个结合植入物或植入物相关材料表面的结合单元(“植入物单元”)和至少一个结合目标分析物或设计为具有预期效果的结合单元(“分析物单元”)组成。单元间通过接头连接。在一些实施例中,IFBM涂层可起到促进目标分析物识别和附着在器件表面的作用。IFBM涂层改善了移植的医疗器件的性能,例如,促进植入物的骨整合。