(EN)
The present disclosure describes a system for making SARS-CoV-virus-like particles (SARS-CoV-VLPs) comprising one or more recombinant vectors which express the SARS-CoV E-protein, the SARS-CoV M-protein, and the SARS-CoV S-protein. Additionally, the present disclosure describes methods of inducing an immune response in a subject comprising administering to the subject a nucleic acid encoding the SARS-CoV E-protein, the SARS-CoV M-protein, and the SARS-CoV S-protein. Methods of inducing an immune response in a subject comprising administering to the subject SARS-CoV-VLPs are also disclosed.
(ZH) 本发明描述制备SARS-CoV-病毒样颗粒(SARS-CoV-VLPs)的系统，所述系统包括一种或多种表达所述SARS-CoV E-蛋白质，所述SARS-CoV M-蛋白质和所述SARS-CoV S-蛋白质的重组载体。另外，本发明描述诱导受试者中免疫应答的方法，所述方法包括向受试者施用编码所述SARS-CoVE-蛋白质，所述SARS-CoV M-蛋白质和所述SARS-CoV S-蛋白质的核酸。还公开了在受试者中诱导免疫应答的方法，所述方法包括向受试者施用SARS-CoV-VLPs。