(EN)
New quinuclidine amide derivatives having the chemical structure of general formula (I) and pharmaceutically acceptable salts thereof including quaternary salts of formula (II) are disclosed; as well as processes for their preparation, pharmaceutical compositions 10 comprising them and their use in therapy as antagonists of M3 muscarinic receptors.
(ZH) 本发明公开了具有通式(I)化学结构的新型奎宁环酰胺衍生物及其药物学上可接受的盐，包括结构式(II)的季铵盐，还公开了它们的制备方法、包含它们的药用组合物以及它们作为M3毒蕈硷受体拮抗剂的医疗用途。