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1. (CN1671351) NSAID-containing topical formulations that demonstrate chemopreventive activity

Office : China
Application Number: 03806943.1 Application Date: 24.01.2003
Publication Number: 1671351 Publication Date: 21.09.2005
Grant Number: 1671351 Grant Date: 23.11.2011
Publication Kind : B
Prior PCT appl.: Application Number:PCTIB2003000611 ; Publication Number:2003061713 Click to see the data
IPC:
A61K 9/06
A61K 9/08
A61K 9/10
A61K 31/192
A61P 17/16
A61P 35/00
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
06
Ointments; Bases therefor
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
08
Solutions
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
185
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19
Carboxylic acids, e.g. valproic acid
192
having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17
Drugs for dermatological disorders
16
Emollients or protectives, e.g. against radiation
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
CPC:
A61K 9/0014
A61K 31/192
A61K 47/06
A61K 47/10
A61K 47/32
A61K 47/36
Applicants: Pharmaqest Pty Ltd.
法玛快斯特有限公司
Inventors: Evans Allan
艾伦·埃文斯
Mckinnon Ross
罗斯·麦金农
Agents: lin xiaogong
永新专利商标代理有限公司 72002
Priority Data: 10310824 06.12.2002 US
60/350,957 25.01.2002 US
Title: (EN) NSAID-containing topical formulations that demonstrate chemopreventive activity
(ZH) 具有化学预防活性的含NSAID的局部用药配方
Abstract: front page image
(EN) Disclosed herein are chemopreventive methods and topical formulations for the prevention and treatment of ultraviolet light-induced skin cancers, pre-cancerous lesions, and hyperproliferative disorders in mammals, such as humans, utilizing doses of non-steroidal anti-inflammatory drugs. Low doses of non-steroidal anti-inflammatory drugs are present in the topical formulations and allow continued regular use over an extended period of time to prevent such disorders. In particular, the present invention is particularly suitable for non-melanoma skin cancers as these cancers tend to appear in areas of the skin that have had excess sun exposure (head, neck and arms) meaning that the chemopreventive agent would not need to be applied over the entire body of the typical patient. Moreover, it is possible to identify 'high-risk' individuals within the populations because people who report one episode of NMSC tend to have a high incidence of a subsequent episode.
(ZH)

本发明描述了利用非甾体类抗炎药物来预防和治疗紫外光诱导的例如人的哺乳动物的皮肤癌、癌前病变以及过度增生性疾病的化学预防方法和局部用药配方。局部用药配方中含有低剂量的非甾体类抗炎药物并可以持续规律地使用相当长的一段时间来预防这些疾病。特别地,本发明特别适合于非黑色素瘤皮肤癌,因为这些癌容易发生于历经过度阳光暴露的皮肤区域(头、颈和臂),这意味着不需要将这种化学预防药物应用到一般患者的整个躯体上。此外,在人群中确认“高危”个体是有可能的,因为有过一次NSMC发作的人倾向于具有高的随后发作的发病率。


Also published as:
MXPA/a/2004/007214KR1020040105706ZA2004/06683EP1476127JP2005521657CA2474343
AU2003237034WO/2003/061713