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1. CN1662512 - Method for producing 3,4-dichloro-n-(2-cyano-phenyl)-5-isothiazole carboxamide

Office China
Application Number 03814967.2
Application Date 17.06.2003
Publication Number 1662512
Publication Date 31.08.2005
Grant Number 1303075
Grant Date 07.03.2007
Publication Kind C
IPC
C07D 275/03
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
275Heterocyclic compounds containing 1, 2-thiazole or hydrogenated 1,2-thiazole rings
02not condensed with other rings
03with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
A01N 43/00
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
43Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
CPC
C07D 275/03
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
275Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
02not condensed with other rings
03with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Applicants Bayer Cropscience AG
拜尔农作物科学股份公司
Inventors Himmler Thomas
T·希姆莱
Agents tai gong wang jingchao
中国专利代理(香港)有限公司
中国专利代理(香港)有限公司
Priority Data 10228731 27.06.2002 DE
Title
(EN) Method for producing 3,4-dichloro-n-(2-cyano-phenyl)-5-isothiazole carboxamide
(ZH) 3,4-二氯-N-(2-氰基-苯基)-5-异噻唑甲酰胺的制备方法
Abstract
(EN)
The invention relates to a novel one-pot method for producing 3,4-dichloro-N-(2-cyano-phenyl)-5-isothiazole carboxamide. According to said method, a) isatoic acid anhydride is reacted with ammonia gas in the presence of dimethylformamide, b) the anthranilic acid amide thus obtained is reacted with 3,4-dichloro-isothiazole carboxylic acid chloride, without being previously isolated, in the presence of an acid acceptor and in the presence of dimethylformamide, and c) the N-[2-(aminocarbonyl)-phenyl]-3,4-dichloro-isothiazole carboxamide thus obtained is reacted with thionyl chloride, phosphorus oxychloride, phosgene or chloromethylene-dimethylammonium chloride, without being previously isolated, in the presence of dimethylformamide.

(ZH)

根据新颖的一锅法,3,4-二氯-N-(2-氰基-苯基)-5-异噻唑甲酰胺可以根据下述的方法制备:a)首先在二甲基甲酰胺存在下使N-羧氨基苯甲酸酐与氨气反应,b)然后,不需要事先分离,在酸受体和二甲基甲酰胺存在下,使所得的邻氨基苯甲酰胺与3,4-二氯异噻唑甲酰氯反应,并且,c)随后,也不需事先分离,在二甲基甲酰胺存在下,使所得的N-[2-(氨基羰基)苯基]-3,4-二氯异噻唑甲酰胺与亚硫酰氯、磷酰氯、光气或氯亚甲基二甲基氯化铵进行反应。