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1. CN1449408 - Synthetic methods for aplidine and new antitumoral derivatives, methods of making and using them

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Office
China
Application Number 01814701.1
Application Date 02.07.2001
Publication Number 1449408
Publication Date 15.10.2003
Publication Kind A
IPC
C07K 11/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
11Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
02cyclic, e.g. valinomycins
C07K 11/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
11Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07K 5/0205
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
02containing at least one abnormal peptide link
0205containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
C07K 5/0808
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
08Tripeptides
0802with the first amino acid being neutral
0804and aliphatic
0808the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
C07K 7/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
02Linear peptides containing at least one abnormal peptide link
C07K 11/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
11Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
Applicants Pharma Mar, S.A.
法马马有限公司
Inventors Rodriguez Ignacio
I·罗德里古滋
Polanco Concepcion
C·珀兰科
Cuevas Felix
F·丘瓦斯
P·曼德兹
C·丘瓦斯
P·加勒戈
S·蒙特
I·曼扎纳雷斯
Agents
中国专利代理(香港)有限公司
Priority Data 0016148.9 30.06.2000 GB
0103750.6 15.02.2001 GB
Title
(EN) Synthetic methods for aplidine and new antitumoral derivatives, methods of making and using them
(ZH) Aplidine及新抗肿瘤衍生物的合成方法、及其制备和使用方法
Abstract
(EN) The invention provides aplidine derivatives and synthetic methods. They are represented by the formula: where the different symbols have the meaning indicated in the description.
(ZH)

本发明提供aplidine衍生物及合成方法。所述化合物由右式表示，其中各种符号的含义在说明书中描述。
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