CN1371362 Process for preparation of isotretinoin

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Application Number 00811998.8

Application Date 24.07.2000

Publication Number 1371362

Publication Date 25.09.2002

Grant Number 1167679

Grant Date 22.09.2004

Publication Kind C

IPC

CPC

Applicants Ranbaxy Laboratories Ltd.
兰贝克赛实验室有限公司

Inventors M. Salman
M·萨勒曼
V.K. Kaul
V·K·考尔
J.S. Babu
J·S·巴比
N·库马尔

Agents chen jianhua
上海专利商标事务所

Priority Data 1037/DEL/99 30.07.1999 IN
09467201 20.12.1999 US

Title

(EN) Process for preparation of isotretinoin

(ZH) 异维甲酸的制备方法

Abstract

(EN) The present invention relates to a process for the preparation of 13-cis isomer of Vitamin A acid, commonly known as isotretinoin, in a single step.

(ZH)

本发明涉及以单步制备维A酸的13-顺式异构体(通称异维甲酸)的方法。

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
C	ACYCLIC OR CARBOCYCLIC COMPOUNDS
403	Derivatives of cyclohexane or of a cyclohexene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene rings, e.g. vitamin A, beta-carotene, beta-ionone
20	having side-chains substituted by carboxyl groups

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
C	ACYCLIC OR CARBOCYCLIC COMPOUNDS
403	Derivatives of cyclohexane or of a cyclohexene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene rings, e.g. vitamin A, beta-carotene, beta-ionone
20	having side-chains substituted by carboxyl groups

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
C	ACYCLIC OR CARBOCYCLIC COMPOUNDS
51	Preparation of carboxylic acids or their salts, halides or anhydrides
347	by reactions not involving formation of carboxyl groups
353	by isomerisation; by change of size of the carbon skeleton

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
C	ACYCLIC OR CARBOCYCLIC COMPOUNDS
403	Derivatives of cyclohexane or of a cyclohexene ; or of cyclohexadiene; , having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene ; or cyclohexadiene; rings, e.g. vitamin A, beta-carotene, beta-ionone
20	having side-chains substituted by carboxyl groups ; or halides, anhydrides, or (thio)esters thereof

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
309	Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
32	having two double bonds between ring members or between ring members and non-ring members

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1. CN1371362 - Process for preparation of isotretinoin