(EN)
The present invention provides a compound of formula (I), or pharmaceutical acceptable salts thereof wherein R1 is C4-12 alkyl, C4-12 alkenyl, C4-12 alkynyl, -(CH2)h-C3-8 cycloalkyl, substituted and unsubstituted -(CH2)h-aryl, substituted and unsubstituted-(CH2)h-het, R2 is substituted and unsubstituted C1-12 alkyl, substituted and unsubstituted C2-12 alkenyl, substituted and unsubstituted C2-12 alkynyl, substituted and unsubstituted-(CH2)h-C3-8 cycloakyl, substituted and unsubstituted -(CH2)h-C3-8 cycloalkenyl, substituted and unsubstituted -(CH2)h-aryl, substituted and unsubstituted -(CH2)h-heterocyclic ring, substituted and unsubstituted -(CH2)i-X-R4 (X is -O-, -S(=O)j-, -NR7-, -S(=O)2NR8-, or -C(=O)-), and -(CH2)iCHR5R6. The compounds are inhibitors of matrix metalloproteinases involved in tissue degradation.
(ZH) 本发明提供通式I化合物或其可药用盐,其中R1是C4-12烷基,C4-12链烯基,C4-12炔基,-(CH2)h-C3-8环烷基,取代的和未取代的-(CH2)h-芳基,取代的和未取代的-(CH2)h-het;R2是取代的和未取代的C1-12烷基,取代的和未取代的C2-12链烯基,取代的和未取代的C2-12炔基,取代的和未取代的-(CH2)h-C3-8环烷基,取代的和未取代的-(CH2)h-C3-8环链烯基,取代的和未取代的-(CH2)h-芳基,取代的和未取代的-(CH2)h-杂环,取代的和未取代-(CH2)i-X-R4(X是-O-,-S(=O)j-,-NR7-,-S(=O)2NR8-,或-C(=O))以及-(CH2)hCHR5R6。该化合物是涉及组织降解的基质金属蛋白酶的抑制剂。