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1. CN1214047 - Novel aromatic piperazines derived from substituted cycloazanes, method for prepairing same, pharmaceutical compsns, and use thereof as drugs

Office
China
Application Number 97193122.4
Application Date 03.02.1997
Publication Number 1214047
Publication Date 14.04.1999
Publication Kind A
IPC
C07D 295/22
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
295Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
22with hetero atoms directly attached to ring nitrogen atoms
C07D 295/20
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
295Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
16acylated on ring nitrogen atoms
20by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
CPC
C07F 5/027
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
5Compounds containing elements of Groups 3 or 13 of the Periodic System
02Boron compounds
027Organoboranes and organoborohydrides
C08F 4/65912
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
4Polymerisation catalysts
42Metals; Metal hydrides; Metallo-organic compounds; Use thereof as catalyst precursors
44selected from light metals, zinc, cadmium, mercury, copper, silver, gold, boron, gallium, indium, thallium, rare earths or actinides
60together with refractory metals, iron group metals, platinum group metals, manganese, rhenium ; technetium; or compounds thereof
62Refractory metals or compounds thereof
64Titanium, zirconium, hafnium or compounds thereof
659Component covered by group C08F4/64 containing a transition metal-carbon bond
65912in combination with an organoaluminium compound
C08F 4/65916
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
4Polymerisation catalysts
42Metals; Metal hydrides; Metallo-organic compounds; Use thereof as catalyst precursors
44selected from light metals, zinc, cadmium, mercury, copper, silver, gold, boron, gallium, indium, thallium, rare earths or actinides
60together with refractory metals, iron group metals, platinum group metals, manganese, rhenium ; technetium; or compounds thereof
62Refractory metals or compounds thereof
64Titanium, zirconium, hafnium or compounds thereof
659Component covered by group C08F4/64 containing a transition metal-carbon bond
65916supported on a carrier, e.g. silica, MgCl2, polymer
C08F 4/65922
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
4Polymerisation catalysts
42Metals; Metal hydrides; Metallo-organic compounds; Use thereof as catalyst precursors
44selected from light metals, zinc, cadmium, mercury, copper, silver, gold, boron, gallium, indium, thallium, rare earths or actinides
60together with refractory metals, iron group metals, platinum group metals, manganese, rhenium ; technetium; or compounds thereof
62Refractory metals or compounds thereof
64Titanium, zirconium, hafnium or compounds thereof
659Component covered by group C08F4/64 containing a transition metal-carbon bond
6592containing at least one cyclopentadienyl ring, condensed or not, e.g. an indenyl or a fluorenyl ring
65922containing at least two cyclopentadienyl rings, fused or not
C08F 10/00
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
10Homopolymers and copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond
C08F 110/02
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
110Homopolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond
02Ethene
Applicants Pierre Fabre Medicament
皮埃尔法博赫药品公司
Inventors S. Halazy
S·哈拉茨
C. Jorand-Lebrum
C·朱兰德-勒布伦
P. Pauwels
P·保威尔斯
P·肖宾
M·马里恩
Agents chen wenbeng
中国国际贸易促进委员会专利商标事务所
Priority Data 9601273 02.02.1996 FR
Title
(EN) Novel aromatic piperazines derived from substituted cycloazanes, method for prepairing same, pharmaceutical compsns, and use thereof as drugs
(ZH) 新的衍生自取代环氮杂烷的芳香哌嗪、它们的制备方法、药物组合物及其作为药物的用途
Abstract
(EN)
Compounds of formula (I), wherein R1 is hydrogen or straight or branched C1-6 alkyl, Z2 is O, NH, CH2O or CH2NH, each of R2 and R3, which are the same or different, is hydrogen or a group selected from straight or branched alkyl, alkoxy, thioether, nitrile, trifluoromethyl or halogen (F, Cl, Br, I), or, when they are adjacent, R2 and R3, taken together, form a 5- or 6-membered ring in order to form, e.g., naphthyl, tetrahydronaphthyl, benzopyrane or benzodioxane, X-Y is NCH2, CH-CH2, C=CH, N or NCH2CH2, and Z1 is -(CH2)n, -(CH2)n CO-, -CO-, -CO(CH2)n-, -SO2-, -SO2(CH2)n-, -O(CH2)n-, -O(CH2)nCO-, -OCO-, -NH(CH2)n-, -NH(CH2)nCO-, -NHCO-, -NHCO(CH2)n-, -NH(CH2)nSO2-, -NHSO2-, -NHSO2(CH2)n-, -CH=CHCO-, -CCCO- -(CH2)nSO2-, -O(CH2)nSO2-.

(ZH)

式Ⅰ化合物,其中R1是氢或直链或支链的C1-6的烷基,Z2是O、NH、CH2O或CH2NH,各R2和R3相同或不同并分别是氢或选自直链或支链的烷基、烷氧基、硫醚、腈基、三氟甲基或卤素(F、Cl、Br、Ⅰ),或当R2和R3相邻时一起形成5-或6-元环以构成如萘基、四氢萘基、苯并吡喃或苯并二噁烷;X-Y代表NCH2、CH-CH2、C=CH、N或NCH2CH2;Z1代表-(CH2)n-、-(CH2)nCO-、-CO-、-CO(CH2)n-、-SO2-、-SO2(CH2)n-、-O(CH2)n-、-O(CH2)nCO-、-OCO-、-NH(CH2)n-、-NH(CH2)nCO-、-NHCO-、-NHCO(CH2)n-、-NH(CH2)nSO2-、-NHSO2-、-NHSO2(CH2)n、-CH=CHCO-、-CCCO-、-(CH2)nSO2-、-O(CH2)nSO2-。