CN116981443 Fully dilutable self-microemulsifying delivery system (SMEDS) for poorly water soluble polar solutes

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Office

China

Application Number 202180094607.9

Application Date 13.12.2021

Publication Number 116981443

Publication Date 31.10.2023

Publication Kind A

IPC

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Applicants THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
多伦多大学管理委员会

Inventors NOURAIL, MOHAMED
M·努拉伊
ACOSTA EDUARDO
E·阿科斯塔
CHENG YU-LING
郑毓玲
DIOSARDI, LUCA
L·迪奥萨迪
RAO VARUN
V·拉奥

Agents 北京市铸成律师事务所 11313
北京市铸成律师事务所 11313

Priority Data 63/132,683 31.12.2020 US

Title

(EN) Fully dilutable self-microemulsifying delivery system (SMEDS) for poorly water soluble polar solutes

(ZH) 用于水溶性差的极性溶质的完全可稀释自微乳化递送系统(SMEDDS)

Abstract

(EN) A self-microemulsification system fully dilutable in an aqueous phase for delivery of one or more polar oil active compounds having a positive characteristic curvature (Cc), the self-microemulsification system fully dilutable in an aqueous phase comprising: a lecithin compound; a hydrophilic linker or a combination of two or more hydrophilic linkers, the hydrophilic linker or the combination of the two or more hydrophilic linkers having a hydrocarbyl group containing 6 to 10 carbon atoms, and the hydrophilic linker or the combination of the two or more HLs having a Cc of about-5 or more negative than about-5; and a carrier oil.

(ZH) 一种用于递送具有正特征曲率(Cc)的一种或多种极性油活性化合物的在水相中完全可稀释的自微乳化系统，所述在水相中完全可稀释的自微乳化系统包含：卵磷脂化合物；亲水性接头或两个或更多个亲水性接头的组合，所述亲水性接头或所述两个或更多个亲水性接头的组合具有一个含有6至10个碳原子的烃基，并且所述亲水性接头或所述两个或更多个HL的组合具有约‑5或比约‑5更负的Cc；以及载体油。

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
9	Medicinal preparations characterised by special physical form
10	Dispersions; Emulsions
107	Emulsions

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
9	Medicinal preparations characterised by special physical form
48	Preparations in capsules, e.g. of gelatin, of chocolate

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
47	Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06	Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
24	containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
47	Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30	Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
34	Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
47	Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06	Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
16	containing nitrogen
18	Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids

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1. CN116981443 - Fully dilutable self-microemulsifying delivery system (SMEDS) for poorly water soluble polar solutes

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
Q	SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
19	Preparations for care of the skin

A	HUMAN NECESSITIES
23	FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES; PREPARATION, TREATMENT OR PRESERVATION THEREOF
L	FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
33	Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof

A	HUMAN NECESSITIES
23	FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES; PREPARATION, TREATMENT OR PRESERVATION THEREOF
P	SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
10	Shaping or working of foodstuffs characterised by the products
30	Encapsulation of particles, e.g. foodstuff additives

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47	Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
44	Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin