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1. CN113880865 - Pyrazolo[1,5-a]pyridine compound as well as preparation method and application thereof

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China
Application Number 202010625119.3
Application Date 01.07.2020
Publication Number 113880865
Publication Date 04.01.2022
Publication Kind A
IPC
C07D 519/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
519Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/ or C07D455/257
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 1/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
A61K 31/4995
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
4995Pyrazines or piperazines forming part of bridged ring systems
CPC
C07D 519/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
519Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 1/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
A61K 31/4995
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
4995Pyrazines or piperazines forming part of bridged ring systems
A61K 31/437
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
4353ortho- or peri-condensed with heterocyclic ring systems
437the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
C07D 471/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Applicants SHANGHAI ALLIST PHARMACEUTICAL TECHNOLOGY CO., LTD.
上海艾力斯医药科技股份有限公司
Inventors LUO HUIBING
罗会兵
ZHOU HUAYONG
周华勇
LI QING
李庆
Agents 中国专利代理(香港)有限公司 72001
中国专利代理(香港)有限公司 72001
Title
(EN) Pyrazolo[1,5-a]pyridine compound as well as preparation method and application thereof
(ZH) 吡唑[1,5-a]吡啶类化合物及其制备方法与应用
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Abstract
(EN) The invention relates to pyrazolo[1,5-a]pyridine compounds as shown in a general formula (I) which is described in the specification, and a preparation method, a pharmaceutical composition and application thereof. In the formula, R1, R2, R3, R4, R5, X, Y and Z are as defined in the specification. The pyrazol[1,5-a]pyridine compound provided by the invention can effectively inhibit fusion of a wild type RET, a mutant type RET, especially a G810R mutant type RET, and RET fusion of KIF5B-RET, CCDC6-RET and the like, is good in safety, and can be used for treating RET-mediated diseases, such as cancers and irritable bowel syndromes.
(ZH) 本发明涉及下述通式(I)所示的吡唑[1，5‑a]吡啶类化合物、其制备方法、药物组合物及应用，式中R1、R2、R3、R4、R5、X、Y、Z如说明书中所定义。本发明所述吡唑[1，5‑a]吡啶类化合物能够有效抑制野生型RET、突变型RET特别是G810R突变型RET、以及KIF5B‑RET和CCDC6‑RET等RET融合，且安全性好，可用于治疗由RET介导的疾病，例如癌症和肠易激综合征。
Related patent documents
WO/2022/002097
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