(EN) The invention relates to a compound as shown in a formula (1a) or (1b) and a preparation method thereof, and application of the compound as shown in the formula (1a) or (1b) and optical isomers, crystal forms and pharmaceutically acceptable salts of the compound as IDH mutant irreversible inhibitors in preparation of antitumor drugs.
(ZH) 本发明涉及一类式(1a)或式(1b)所示的化合物及其制备方法,及式(1a)或式(1b)化合物及其各光学异构体、各晶型、药学上可接受的盐作为IDH突变体不可逆抑制剂在抗肿瘤药物制备中的用途。