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1. CN113491700 - Application of taurolidine in virus resistance

Office
China
Application Number 202110752333.X
Application Date 02.07.2021
Publication Number 113491700
Publication Date 12.10.2021
Publication Kind A
IPC
A61K 31/549
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
54having six-membered rings with at least one nitrogen and at least one sulfur as the ring hetero atoms, e.g. sulthiame
549having two or more nitrogen atoms in the same ring, e.g. hydrochlorothiazide
A61P 31/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 31/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
16for influenza or rhinoviruses
CPC
A61K 31/549
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
54having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
549having two or more nitrogen atoms in the same ring, e.g. hydrochlorothiazide
A61P 31/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 31/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
16for influenza or rhinoviruses
A61P 31/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
A61P 31/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
18for HIV
Applicants INSTITUTE OF MILITARY VETERINARY MEDICINE, ACADEMY OF MILITARY SCIENCES
军事科学院军事医学研究院军事兽医研究所
CHANGCHUN MAILING BIOLOGICAL ENGINEERING CO., LTD.
长春迈灵生物工程有限公司
Inventors GAO YUWEI
高玉伟
SU ZHONG
苏忠
LI YUANGUO
李元果
LI SONG
李松
LYU CHAOXIANG
吕朝相
WANG TIECHENG
王铁成
ZHONG WU
钟武
XIANG HAIYANG
向海洋
ZHOU TONG
周彤
SUN WEIYANG
孙伟洋
WANG XUEFENG
王雪峰
ZHOU BO
周博
LI ENTAO
李恩涛
FENG NA
冯娜
ZHAO YONGKUN
赵永坤
YANG SONGTAO
杨松涛
XIA XIANZHU
夏咸柱
Agents 中国贸促会专利商标事务所有限公司 11038
Title
(EN) Application of taurolidine in virus resistance
(ZH) 牛磺罗定在抗病毒中的应用
Abstract
(EN) The invention provides an application of taurolidine in virus resistance. Specifically, the invention provides use of the taurolidine or a derivative thereof, a prodrug, a solvate or a pharmaceutically acceptable salt thereof, or a composition containing the taurolidine or the derivative thereof, the prodrug, the solvate or the pharmaceutically acceptable salt thereof in preparation of antiviral drugs. Research results show that the taurolidine can significantly inhibit influenza virus and coronavirus at a cellular level. In addition, in-vivo experiments prove that taurolidine has a remarkable protection effect on lungs and can prolong the survival time of mice infected with influenza viruses or SARS-CoV-2 viruses. Therefore, the taurolidine can be used for preventing and treating lung diseases caused by the influenza virus or the coronavirus. The research result of the application expands the efficacy range of the taurolidine, and provides a research basis and opens up a new direction for research and development of drugs for preventing or treating pulmonary infection caused by the viruses.
(ZH) 本申请提供了牛磺罗定在抗病毒中的应用。具体地,本申请提供牛磺罗定或其衍生物、前药、溶剂合物或药学上可接受的盐、或含有牛磺罗定或其衍生物、前药、溶剂合物或药学上可接受的盐的组合物在制备抗病毒药物中的用途。研究结果显示,牛磺罗定在细胞水平上能够显著抑制流感病毒和冠状病毒。另外,体内实验证实牛磺罗定对肺脏具有显著的保护作用,能延长流感病毒或SARS‑CoV‑2病毒感染小鼠的生存时间。表明牛磺罗定可用于流感病毒或冠状病毒引起的肺部疾病的预防和治疗。本申请的研究结果拓展了牛磺罗定的功效范围,为预防或治疗由病毒引起肺部感染药物的研发提供了研究基础和开辟了新方向。
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