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1. CN113015526 - SPIROCYCLIC 2,3-DIHYDRO-7-AZAINDOLE COMPOUNDS AND USES THEREOF

Office
China
Application Number 201980074628.7
Application Date 19.09.2019
Publication Number 113015526
Publication Date 22.06.2021
Publication Kind A
IPC
A61K 31/437
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
4353ortho- or peri-condensed with heterocyclic ring systems
437the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07D 471/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
CPC
C07D 471/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
A61K 31/437
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
4353ortho- or peri-condensed with heterocyclic ring systems
437the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants F. HOFFMANN-LA ROCHE AG
豪夫迈·罗氏有限公司
Inventors MALHOTRA SUSHANT
S·马尔霍特拉
STIVALA CRAIG
C·斯蒂瓦拉
WEI BINQING
魏斌清
CHAN BRYAN K
B·K·陈
HEFFRON TIMOTHY
T·海夫伦
LAINCHBURY MICHAEL
M·兰伯里
MARTIN ANTHONY
A·马丁
PANCHAL TERRY AARON
T·A·潘查
SEWARD EILEEN MARY
E·M·斯沃德
BLENCH TOBY
T·布兰奇
CARTWRIGHT MATTHEW W
M·W·卡特维特
DECHAUX ELSA AMANDINE
E·A·德肖
ELLIOTT RICHARD
R·艾略特
GANCIA EMANUELA
E·甘西亚
Agents 北京坤瑞律师事务所 11494
Priority Data PCT/CN2018/106536 19.09.2018 CN
Title
(EN) SPIROCYCLIC 2,3-DIHYDRO-7-AZAINDOLE COMPOUNDS AND USES THEREOF
(ZH) 螺环2,3-二氢-7-氮杂吲哚化合物及其用途
Abstract
(EN) Spirocyclic 2,3-dihydro-7-azaindole compounds of formula (I), variations thereof, and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the spirocyclic 2,3-dihydro-7-azaindole compounds.
(ZH) 本发明提供式(I)的螺环2,3‑二氢‑7‑氮杂吲哚化合物:所述式的变体的所述化合物,以及所述化合物作为HPK1(造血激酶1)抑制剂的用途。所述化合物可用于治疗HPK1依赖性疾患以及增强免疫应答。本公开还描述了抑制HPK1的方法、治疗HPK1依赖性疾患的方法、用于增强免疫应答的方法以及用于制备所述螺环2,3‑二氢‑7‑氮杂吲哚化合物的方法。
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