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1. CN111808746 - Ultrasonic sound field conformal gene transfection device

Office
China
Application Number 202010734848.2
Application Date 27.07.2020
Publication Number 111808746
Publication Date 23.10.2020
Publication Kind A
IPC
C12M 1/42
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
42Apparatus for the treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic wave
C12M 1/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
CPC
C12M 35/04
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
35Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
04Mechanical means, e.g. sonic waves, stretching forces, pressure or shear stimuli
Applicants SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY, CHINESE ACADEMY OF SCIENCES
中国科学院深圳先进技术研究院
Inventors YAN FEI
严飞
JIANG TIAN'AN
蒋天安
XIE LITING
谢丽婷
ZOU JUNJIE
邹俊杰
Agents 深圳中一联合知识产权代理有限公司 44414
Title
(EN) Ultrasonic sound field conformal gene transfection device
(ZH) 一种超声声场适形的基因转染装置
Abstract
(EN) The invention provides an ultrasonic sound field conformal gene transfection device. The device comprises: an ultrasonic transducer (1) used for emitting ultrasonic waves; an ultrasonic sound field conformal device (2) used for containing a compound of genes, cells and ultrasonic response particles, wherein the shape and the size of the ultrasonic sound field conformal device (2) are determined according to the sound field of the ultrasonic waves; and a focal length adapter (3) used for fixing the ultrasonic sound field conformal device (2) at a preset position, wherein the preset position isdetermined according to the sound field position of the ultrasonic waves. According to the gene transfection device provided by the invention, conformal coverage of an ultrasonic sound field can be realized, so that maximum utilization of ultrasonic energy is realized, and the gene transfection efficiency is improved.
(ZH) 本申请提供了一种超声声场适形的基因转染装置,包括:超声换能器(1),用于发射超声波;超声声场适形器(2),用于容纳基因、细胞和超声响应颗粒的复合物,所述超声声场适形器(2)的形状以及大小根据所述超声波的声场进行确定;焦距适配器(3),用于将所述超声声场适形器(2)固定于预设位置,所述预设位置根据所述超声波的声场位置进行确定。本申请提供的基因转染装置能够实现对超声声场的适形覆盖,进而实现对超声能量的最大化利用,由此提高了基因转染效率。
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