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1. CN111795948 - Optical biosensor and COVID-19 virus detection device

Office
China
Application Number 202010635235.3
Application Date 03.07.2020
Publication Number 111795948
Publication Date 20.10.2020
Grant Number 111795948
Grant Date 19.04.2022
Publication Kind B
IPC
G01N 21/45
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
17Systems in which incident light is modified in accordance with the properties of the material investigated
41Refractivity; Phase-affecting properties, e.g. optical path length
45using interferometric methods; using Schlieren methods
G01N 33/569
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
569for microorganisms, e.g. protozoa, bacteria, viruses
CPC
G01N 21/45
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
17Systems in which incident light is modified in accordance with the properties of the material investigated
41Refractivity; Phase-affecting properties, e.g. optical path length
45using interferometric methods; using Schlieren methods
G01N 33/56983
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
569for microorganisms, e.g. protozoa, bacteria, viruses
56983Viruses
G01N 2021/458
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
17Systems in which incident light is modified in accordance with the properties of the material investigated
41Refractivity; Phase-affecting properties, e.g. optical path length
45using interferometric methods; using Schlieren methods
458using interferential sensor, e.g. sensor fibre, possibly on optical waveguide
G01N 2333/165
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2333Assays involving biological materials from specific organisms or of a specific nature
005from viruses
08RNA viruses
165Coronaviridae, e.g. avian infectious bronchitis virus
Applicants WESTLAKE UNIVERSITY
西湖大学
Inventors RONG GUOGUANG
荣国光
MUHAMMAD SOWAN
默罕默德·萨万
BIAN SUMIN
卞素敏
SU YI
苏逸
LIU XINXIN
刘鑫鑫
Agents 上海晨皓知识产权代理事务所(普通合伙) 31260
Title
(EN) Optical biosensor and COVID-19 virus detection device
(ZH) 光学生物传感器及COVID-19病毒检测装置
Abstract
(EN) The invention belongs to the technical field of biological detection, and discloses an optical biosensor and a COVID-19 virus detection device. The optical biosensor provided by the invention comprises a monocrystalline silicon substrate and a nano-porous silicon film optical device arranged on the monocrystalline silicon substrate, and the nano-porous silicon film optical device comprises a porous silicon single-layer interference film, a porous silicon Bragg reflector or a porous silicon micro resonant cavity; a composite metal film is deposited on the surface of the nano-porous silicon filmoptical device, and a biological probe is coated on the surface of the nano-porous silicon film optical device in sequence. By designing the structure of the nano-porous silicon film optical device and depositing the composite metal film on the surface of the nano-porous silicon film optical device, the detection sensitivity of the optical biosensor is remarkably improved, and the optical biosensor is suitable for detecting COVID-19 viruses and other pathogens.
(ZH) 本发明属于生物检测技术领域,公开了一种光学生物传感器及COVID‑19病毒检测装置。本发明所提供的光学生物传感器,包括单晶硅基底及设于所述单晶硅基底上的纳米多孔硅薄膜光学器件,所述纳米多孔硅薄膜光学器件包括多孔硅单层干涉膜、多孔硅布拉格反射镜或多孔硅微谐振腔;所述纳米多孔硅薄膜光学器件的表面依次沉积有复合金属薄膜、包被有生物探针。本发明通过对纳米多孔硅薄膜光学器件的结构设计、以及在纳米多孔硅薄膜光学器件表面沉积复合金属薄膜,显著提高了光学生物传感器的检测灵敏度,适用于对COVID‑19病毒等病原体的检测。
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