Processing

Please wait...

Settings

Settings

Goto Application

1. CN111748016 - Self-assembled short-chain polypeptide based on atypical hydrophobic amino acid and application thereof

Office
China
Application Number 202010638716.X
Application Date 03.07.2020
Publication Number 111748016
Publication Date 09.10.2020
Publication Kind A
IPC
C07K 7/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04Linear peptides containing only normal peptide links
06having 5 to 11 amino acids
A61K 47/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
16containing nitrogen
18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
A61K 47/42
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
42Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
CPC
C07K 7/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04Linear peptides containing only normal peptide links
06having 5 to 11 amino acids
A61K 47/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
16containing nitrogen, ; e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
A61K 47/42
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
42Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
Applicants WEST CHINA HOSPITAL, SICHUAN UNIVERSITY
四川大学华西医院
Inventors QIU FENG
邱峰
PENG FEI
彭飞
ZHANG WENSHENG
张文胜
LIU JING
刘静
Agents 成都高远知识产权代理事务所(普通合伙) 51222
成都高远知识产权代理事务所(普通合伙) 51222
Title
(EN) Self-assembled short-chain polypeptide based on atypical hydrophobic amino acid and application thereof
(ZH) 一种基于非典型疏水性氨基酸的自组装短肽及其应用
Abstract
(EN) The invention relates to a short-chain polypeptide and application of the short-chain polypeptide as a carrier of a hydrophobic drug. The amino acid sequence of the short-chain polypeptide is composedof 2-10 glutamine and 0-5 amino acids X, wherein X can be tyrosine, threonine, glycine, asparagine, serine, alanine, valine, phenylalanine, leucine, isoleucine or tryptophan. The short-chain polypeptide disclosed by the invention can be used for loading a plurality of hydrophobic drugs through a molecular self-assembly mechanism to form nanospheres with uniform particle sizes, so that the drugs are effectively transferred into cells or tissues to exert the drug effect, and the short-chain polypeptide is safe, free of obvious cytotoxicity and simple in preparation process, and is a hydrophobicdrug carrier with a great development prospect.
(ZH) 本发明涉及一种短肽及其作为疏水药物的载体的应用。所涉及的短肽氨基酸序列为由2~10个谷氨酰胺以及0~5个氨基酸X组成,其中X可以为酪氨酸、苏氨酸、甘氨酸、天冬酰胺、丝氨酸、丙氨酸、缬氨酸、苯丙氨酸、亮氨酸、异亮氨酸或色氨酸。本发明的短肽,能够通过分子自组装的机制装载多种疏水药物,形成粒径均匀的纳米球,从而将药物有效地转运进入细胞或组织发挥其药效,安全无明显细胞毒性,制剂工艺简单,是一种极具开发前景的疏水药物的载体。
Related patent documents