(EN) The invention relates to the field of biological medicines, and particularly relates to a contrast agent film-forming agent composition, a contrast agent film-forming lipid solution containing the contrast agent film-forming agent composition, a contrast agent containing the contrast agent film-forming lipid solution and a preparation method thereof. The contrast agent film-forming agent composition comprises lipid, an emulsifier and a surface charge modifier, wherein relative to 100 parts by weight of the lipid, the content of the emulsifier is 20-50 parts by weight, and the content of the surface charge modifier is 10-35 parts by weight; and the lipid is carboxylated phospholipid, and the surface charge modifier is polyelectrolyte. According to the composition and the preparation method,nano-droplets of the obtained contrast agent have more uniform particle size, higher stability and better controllability, have a lower ultrasonic gasification threshold value, can also be used as aphotoacoustic contrast agent or a multi-modal contrast agent, and have a wide application prospect.
(ZH) 本发明涉及生物医药领域，具体涉及一种造影剂成膜剂组合物、含有该造影剂成膜剂组合物的造影剂成膜脂液，含有该造影剂成膜脂液的造影剂及其制备方法。该造影剂成膜剂组合物包括脂质、乳化剂和表面电荷修饰剂，相对于100重量份的所述脂质，所述乳化剂的含量为20‑50重量份，所述表面电荷修饰剂的含量为10‑35重量份；其中，所述脂质为羧基化的磷脂，所述表面电荷修饰剂为聚电解质。本发明的组合物和制备方法能够使得所得的造影剂的纳米液滴具有更均一的粒径、更高的稳定性和更好的可控性，并且具有更低的超声气化阈值，还能够用作光声造影剂或多模态造影剂，具有广阔的应用前景。
