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1. CN111729093 - Contrast agent film-forming agent composition, contrast agent film-forming lipid solution, contrast agent and preparation method thereof

Office
China
Application Number 202010604201.8
Application Date 29.06.2020
Publication Number 111729093
Publication Date 02.10.2020
Grant Number 111729093
Grant Date 24.05.2022
Publication Kind B
IPC
A61K 49/22
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
22Echographic preparations; Ultrasound imaging preparations
A61K 49/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
A61K 41/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
41Medicinal preparations obtained by treating materials with wave energy or particle radiation
A61K 9/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
06Ointments; Bases therefor
B82Y 40/00
BPERFORMING OPERATIONS; TRANSPORTING
82NANOTECHNOLOGY
YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE  OR TREATMENT OF NANOSTRUCTURES
40Manufacture or treatment of nanostructures
B82Y 20/00
BPERFORMING OPERATIONS; TRANSPORTING
82NANOTECHNOLOGY
YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE  OR TREATMENT OF NANOSTRUCTURES
20Nanooptics, e.g. quantum optics or photonic crystals
CPC
A61K 49/226
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
22Echographic preparations; Ultrasound imaging preparation ; Optoacoustic imaging preparations
222characterised by a special physical form, e.g. emulsions, liposomes
226Solutes, emulsions, suspensions, dispersions, semi-solid forms, e.g. hydrogels
A61K 49/0002
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
0002General or multifunctional contrast agents, e.g. chelated agents
A61K 41/0057
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
41Medicinal preparations obtained by treating materials with wave energy or particle radiation ; ; Therapies using these preparations
0057Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
A61K 9/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
06Ointments; Bases therefor; ; Other semi-solid forms, e.g. creams, sticks, gels
A61K 41/0071
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
41Medicinal preparations obtained by treating materials with wave energy or particle radiation ; ; Therapies using these preparations
0057Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
0071PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
B82Y 20/00
BPERFORMING OPERATIONS; TRANSPORTING
82NANOTECHNOLOGY
YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
20Nanooptics, e.g. quantum optics or photonic crystals
Applicants NANJING CHAOWEIJING BIOTECHNOLOGY CO., LTD.
南京超维景生物科技有限公司
Inventors DONG FEIHONG
董飞宏
AN JIAN
安健
ZHANG JIABIN
张嘉宾
GUO WENYU
郭雯雨
ZHANG JUE
张珏
Agents 北京布瑞知识产权代理有限公司 11505
Title
(EN) Contrast agent film-forming agent composition, contrast agent film-forming lipid solution, contrast agent and preparation method thereof
(ZH) 一种造影剂成膜剂组合物、造影剂成膜脂液、造影剂及其制备方法
Abstract
(EN) The invention relates to the field of biological medicines, and particularly relates to a contrast agent film-forming agent composition, a contrast agent film-forming lipid solution containing the contrast agent film-forming agent composition, a contrast agent containing the contrast agent film-forming lipid solution and a preparation method thereof. The contrast agent film-forming agent composition comprises lipid, an emulsifier and a surface charge modifier, wherein relative to 100 parts by weight of the lipid, the content of the emulsifier is 20-50 parts by weight, and the content of the surface charge modifier is 10-35 parts by weight; and the lipid is carboxylated phospholipid, and the surface charge modifier is polyelectrolyte. According to the composition and the preparation method,nano-droplets of the obtained contrast agent have more uniform particle size, higher stability and better controllability, have a lower ultrasonic gasification threshold value, can also be used as aphotoacoustic contrast agent or a multi-modal contrast agent, and have a wide application prospect.
(ZH) 本发明涉及生物医药领域,具体涉及一种造影剂成膜剂组合物、含有该造影剂成膜剂组合物的造影剂成膜脂液,含有该造影剂成膜脂液的造影剂及其制备方法。该造影剂成膜剂组合物包括脂质、乳化剂和表面电荷修饰剂,相对于100重量份的所述脂质,所述乳化剂的含量为20‑50重量份,所述表面电荷修饰剂的含量为10‑35重量份;其中,所述脂质为羧基化的磷脂,所述表面电荷修饰剂为聚电解质。本发明的组合物和制备方法能够使得所得的造影剂的纳米液滴具有更均一的粒径、更高的稳定性和更好的可控性,并且具有更低的超声气化阈值,还能够用作光声造影剂或多模态造影剂,具有广阔的应用前景。
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