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1. CN111690058 - Antibodies with neutralizing activity against coronavirus and application thereof

Office
China
Application Number 202010236256.8
Application Date 30.03.2020
Publication Number 111690058
Publication Date 22.09.2020
Grant Number 111690058
Grant Date 05.02.2021
Publication Kind B
IPC
C07K 16/10
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
08against material from viruses
10from RNA viruses
C07K 16/46
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
46Hybrid immunoglobulins
C12N 15/13
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
12Genes encoding animal proteins
13Immunoglobulins
A61K 39/42
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
42viral
A61P 31/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
G01N 33/569
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
569for microorganisms, e.g. protozoa, bacteria, viruses
CPC
A61P 31/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
C07K 16/10
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
08against material from viruses
10from RNA viruses ; , e.g. hepatitis E virus
C07K 2317/31
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
30characterized by aspects of specificity or valency
31multispecific
C07K 2317/56
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
50characterized by immunoglobulin fragments
56variable (Fv) region, i.e. VH and/or VL
C07K 2317/565
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
50characterized by immunoglobulin fragments
56variable (Fv) region, i.e. VH and/or VL
565Complementarity determining region [CDR]
C07K 2317/76
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
70characterized by effect upon binding to a cell or to an antigen
76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Applicants SANYOU BIO INC.
三优生物医药(上海)有限公司
SHANGHAI ZJ BIO-TECH CO., LTD.
上海之江生物科技股份有限公司
Inventors LANG GUOJUN
郎国竣
SHAO JUNBIN
邵俊斌
TAN YONGCONG
谭永聪
YAO HANGPING
姚航平
ZHANG WENHAI
张文海
YAN XINTIAN
闫鑫甜
HU YUHAO
胡宇豪
KONG CHAO
孔超
ZHOU YUNHUA
周蕴华
YAN RUN
闫闰
SUN XINGLU
孙兴鲁
WU QI
吴琪
YAO FUJIA
姚福家
TIAN MEI
田美
HAN XIAOGANG
韩晓刚
Agents 北京市中咨律师事务所 11247
北京市中咨律师事务所 11247
Title
(EN) Antibodies with neutralizing activity against coronavirus and application thereof
(ZH) 针对冠状病毒的具有中和活性的抗体及其用途
Abstract
(EN) The present invention relates to an antibody or an antigen-binding fragment that specifically bind to coronavirus S protein, a multispecific antibody, and an antibody combination. The invention also relates to nucleic acids encoding the antibody or the antigen-binding fragment, and the multispecific antibody and host cells comprising the same, and a method for making the antibody or the antigen-binding fragment, and the multispecific antibody. Furthermore, the present invention relates to the prophylactic, therapeutic and/or diagnostic application of the antibody or the antigen binding fragment, the multispecific antibody and the antibody combination.
(ZH) 本发明涉及特异性结合冠状病毒S蛋白的抗体或抗原结合片段、多特异性抗体、以及抗体组合。本发明还涉及编码所述抗体或抗原结合片段、多特异性抗体的核酸及包含其的宿主细胞,以及制备所述抗体或抗原结合片段、多特异性抗体的方法。此外,本发明涉及所述抗体或抗原结合片段、多特异性抗体、抗体组合的预防、治疗和/或诊断用途。
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