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1. CN111647066 - WT1 polypeptide tumor inhibitor

Office
China
Application Number 202010624208.6
Application Date 01.07.2020
Publication Number 111647066
Publication Date 11.09.2020
Grant Number 111647066
Grant Date 18.12.2020
Publication Kind B
IPC
C07K 14/47
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
A61K 39/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
CPC
C07K 14/4748
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
4701not used
4748Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
A61K 39/001153
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
0005Vertebrate antigens
0011Cancer antigens
001152Transcription factors, e.g. SOX, c-MYC
001153Wilms tumor 1 [WT1]
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61K 2039/812
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
80Vaccine for a specifically defined cancer
812Breast
A61K 2039/82
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
80Vaccine for a specifically defined cancer
82Colon
Applicants WEITAIYING (SHANGHAI) BIOTECHNOLOGY CO., LTD.
维肽瀛(上海)生物技术有限公司
Inventors LI KUNPENG
李坤鹏
Agents 北京高航知识产权代理有限公司 11530
Title
(EN) WT1 polypeptide tumor inhibitor
(ZH) WT1多肽肿瘤抑制剂
Abstract
(EN) The invention discloses and provides an antigen composed of nine polypeptides from a WT1 protein sequence. According to the antigen, a WT1 target is analyzed through computer software, sequence splitting is carried out on the part, with the best antigenicity, of a protein, and split polypeptides are combined into nine long peptides as antigen sequences. The polypeptide combination disclosed by theinvention has the advantages of better antitumor effect and wider lineage.
(ZH) 本发明公开了提供一种由9条来自于WT1蛋白序列的多肽组成的抗原。该抗原是通过计算机软件对WT1靶点进行了分析,将该蛋白抗原性最好的一部分进行序列拆分,组合成为9条长肽做为抗原序列。本发明的多肽组合具有抗肿瘤效果更好,谱系更广的优点。
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